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T-bet orchestrates CD8αα IEL differentiation.T 细胞转录因子 T-bet 调控 CD8αα 肠上皮内淋巴细胞的分化。
Immunity. 2014 Aug 21;41(2):169-71. doi: 10.1016/j.immuni.2014.08.003.
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Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.转录因子T-bet调节上皮内淋巴细胞的功能成熟。
Immunity. 2014 Aug 21;41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.
3
T-bet in disease.T 细胞激活因子在疾病中的作用。
Nat Immunol. 2011 Jun 20;12(7):597-606. doi: 10.1038/ni.2059.
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The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.转录因子 T-bet 由 IL-15 和胸腺激动剂选择诱导，并控制 CD8αα(+)上皮内淋巴细胞的发育。
Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.
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CD8αα intraepithelial lymphocytes arise from two main thymic precursors.CD8αα上皮内淋巴细胞起源于两种主要的胸腺前体细胞。
Nat Immunol. 2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.
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T-bet employs diverse regulatory mechanisms to repress transcription.T-bet 通过多种调控机制来抑制转录。
Trends Immunol. 2012 Feb;33(2):78-83. doi: 10.1016/j.it.2011.10.005. Epub 2011 Nov 29.
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T-bet expression is regulated by EGR1-mediated signaling in activated T cells.T-bet的表达在活化的T细胞中受EGR1介导的信号传导调控。
Clin Immunol. 2009 Jun;131(3):385-94. doi: 10.1016/j.clim.2009.02.009.
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Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut.肠道中CD4CD8αα上皮内淋巴细胞的谱系重编程。
BMB Rep. 2016 Jan;49(1):11-7. doi: 10.5483/BMBRep.2016.49.1.242.
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The calculus of integrating differentiation: timing control of T-bet.整合分化的演算：T-bet的时间控制
Immunity. 2009 May;30(5):666-8. doi: 10.1016/j.immuni.2009.04.008.
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The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection.转录因子 T-Bet 是急性病毒感染期间维持最佳 I 型滤泡辅助性 T 细胞所必需的。
Front Immunol. 2019 Mar 29;10:606. doi: 10.3389/fimmu.2019.00606. eCollection 2019.
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Advances in cancer immunotherapy: historical perspectives, current developments, and future directions.癌症免疫疗法的进展：历史回顾、当前发展及未来方向。
Mol Cancer. 2025 May 7;24(1):136. doi: 10.1186/s12943-025-02305-x.
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Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders.胃肠道NK细胞和T细胞淋巴增殖性疾病的细胞起源与发病机制
Cancers (Basel). 2022 May 18;14(10):2483. doi: 10.3390/cancers14102483.
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Retinoid Signaling in Intestinal Epithelial Cells Is Essential for Early Survival From Gastrointestinal Infection.肠上皮细胞中的类视黄醇信号对于早期从胃肠道感染中存活是必需的。
Front Immunol. 2020 Oct 8;11:559635. doi: 10.3389/fimmu.2020.559635. eCollection 2020.
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Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.肠上皮内淋巴细胞：维持肠道免疫耐受的守护者和调节肠道免疫的调控者。
J Leukoc Biol. 2021 Feb;109(2):339-347. doi: 10.1002/JLB.3RU0220-111. Epub 2020 Jul 17.
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IL-15 in the Combination Immunotherapy of Cancer.白细胞介素 15 在癌症联合免疫治疗中的作用
Front Immunol. 2020 May 19;11:868. doi: 10.3389/fimmu.2020.00868. eCollection 2020.
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Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer.白细胞介素-15（异常）调节淋巴组织稳态：对自身免疫和癌症治疗的影响。
J Exp Med. 2020 Jan 6;217(1). doi: 10.1084/jem.20191062.
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CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.小鼠肠道中的CD8αα TCRαβ上皮内淋巴细胞
Dig Dis Sci. 2016 Jun;61(6):1451-60. doi: 10.1007/s10620-015-4016-y. Epub 2016 Jan 14.
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Transcription Factor T-Bet in Atlantic Salmon: Characterization and Gene Expression in Mucosal Tissues during Aeromonas Salmonicida Infection.大西洋鲑鱼中的转录因子T-Bet：杀鲑气单胞菌感染期间黏膜组织中的特性及基因表达
Front Immunol. 2015 Jul 6;6:345. doi: 10.3389/fimmu.2015.00345. eCollection 2015.
本文引用的文献
1
Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.转录因子T-bet调节上皮内淋巴细胞的功能成熟。
Immunity. 2014 Aug 21;41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.
2
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.转录因子 T-bet 由 IL-15 和胸腺激动剂选择诱导，并控制 CD8αα(+)上皮内淋巴细胞的发育。
Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.
3
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.从共同前体细胞分化为 1 型固有淋巴样细胞（ILC）和所有辅助样先天淋巴样细胞谱系。
Cell. 2014 Apr 10;157(2):340-356. doi: 10.1016/j.cell.2014.03.030.
4
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.转录因子 Runx3 和 ThPOK 的相互表达调节肠道 CD4⁺ T 细胞免疫。
Nat Immunol. 2013 Mar;14(3):271-80. doi: 10.1038/ni.2518. Epub 2013 Jan 20.
5
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells.T 细胞特异性转录因子（T-bet）梯度控制 CCR6+RORγt+固有淋巴细胞的命运和功能。
Nature. 2013 Feb 14;494(7436):261-5. doi: 10.1038/nature11813. Epub 2013 Jan 16.
6
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.克隆删除和逃避阴性选择的自身反应性胸腺细胞的命运。
Nat Immunol. 2012 Apr 29;13(6):569-78. doi: 10.1038/ni.2292.
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The light and dark sides of intestinal intraepithelial lymphocytes.肠上皮内淋巴细胞的光明与黑暗面。
Nat Rev Immunol. 2011 Jun 17;11(7):445-56. doi: 10.1038/nri3007.
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Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.胸腺中预选和后选TCRαβ⁺上皮内淋巴细胞前体的鉴定。
Immunity. 2006 Oct;25(4):631-41. doi: 10.1016/j.immuni.2006.08.018.
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Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes.缺乏CCR9 CC趋化因子受体的小鼠表现出早期T细胞和B细胞发育的轻度受损以及T细胞受体γδ(+)肠道上皮内淋巴细胞数量减少。
Blood. 2001 Nov 1;98(9):2626-32. doi: 10.1182/blood.v98.9.2626.
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Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes.α4β7和αEβ7整合素在胸腺细胞、肠上皮淋巴细胞和外周淋巴细胞上的分布。
Eur J Immunol. 1996 Apr;26(4):897-905. doi: 10.1002/eji.1830260427.
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