O'Neill Jenna L, Moustafa Farah, Teague Daniel, Huang William W
Wake Forest School of Medicine.
Dermatol Online J. 2014 Aug 17;20(8):13030/qt0hd858q9.
Subcutaneous sarcoidosis is a rare variant of cutaneous sarcoidosis, which typically presents as single or multiple, indurated, ill-defined plaques, typically on the upper extremities. Granulomas consisting of macrophages with multinucleated giant cells and sparse lymphocytic inflammation are confined to the subcutaneous tissue, rather than to their usual location within the dermis in typical lesions of cutaneous sarcoidosis. An association between subcutaneous sarcoidosis and systemic involvement has been reported, although response to treatment and prognosis remain good. We report a case of a middle-aged woman with subcutaneous sarcoidosis, with negative work-up for systemic involvement of sarcoidosis. Interestingly, family history was significant for a son who died from complications of pulmonary sarcoidosis. The patient was successfully treated with a tapering course of oral prednisone in combination with hydroxychloroquine.
皮下结节病是皮肤结节病的一种罕见变体，通常表现为单个或多个、硬结性、边界不清的斑块，多见于上肢。由含有多核巨细胞的巨噬细胞和稀疏淋巴细胞炎症组成的肉芽肿局限于皮下组织，而非典型皮肤结节病病变中通常位于真皮内的位置。虽然有报道称皮下结节病与全身受累有关，但治疗反应和预后仍然良好。我们报告一例中年女性皮下结节病患者，其结节病全身受累检查结果为阴性。有趣的是，家族史中有意义的是，患者的儿子死于肺结节病并发症。该患者通过逐渐减量的口服泼尼松联合羟氯喹成功治愈。
