Marcoval Joaquim, Moreno Abelardo, Mañá Juan, Peyri Jordi
Department of Dermatology, Hospital de Bellvitge, IDIBELL, University of Barcelona, C/Feixa Llarga s/n, Hospitalet de Llobregat, 08907-Barcelona, Spain.
Dermatol Clin. 2008 Oct;26(4):553-6, ix. doi: 10.1016/j.det.2008.05.003.
Subcutaneous sarcoidosis has been reported to occur in 1.4% to 6% of patients with systemic sarcoidosis. Most reported cases are in women, most often in their fifth and sixth decades, and appear as multiple, asymptomatic, hardly indurated subcutaneous nodules without changes in the overlying epidermis. The lesions are characteristically located in the upper extremities, mainly in the forearms, and usually are bilateral and asymmetric. In most cases the lesions appear at the beginning of systemic sarcoidosis and are not associated with chronic fibrotic disease. Histopathologically, sarcoidosis is characterized by noncaseating naked granulomas involving fat lobules, with minimal to no septal involvement.
据报道，皮下结节病在系统性结节病患者中的发生率为1.4%至6%。大多数报告病例为女性，最常见于五、六十岁，表现为多个无症状、几乎不硬结的皮下结节，表皮无变化。病变特征性地位于上肢，主要在手臂，通常为双侧且不对称。在大多数情况下，病变出现在系统性结节病开始时，与慢性纤维化疾病无关。组织病理学上，结节病的特征是累及脂肪小叶的非干酪样裸结节，间隔受累最小或无受累。
