Li Yan-Hong, Liu Ling
Department of Cardiology, the Second Xiangya Hospital, Central South University, #139 Middle Renmin Road, Changsha, Hunan 410011, PR China.
Lipids Health Dis. 2014 Aug 23;13:136. doi: 10.1186/1476-511X-13-136.
Excessive energy storage of adipose tissue makes contribution to the occurrence and progression of obesity, which accompanies with multiple adverse complications, such as metabolic syndrome, cardiovascular diseases. It is well known that apolipoprotein E, as a component of lipoproteins, performs a key role in maintaining plasma lipoproteins homeostasis. Interestingly, apolipoprotein E is highly expressed in adipocyte and has positive relation with body fat mass. Apolipoprotein E knock-out mice show small fat mass compared to wild type mice. Moreover, adipocyte deficiency in apolipoprotein E shows impaired lipoproeteins internalization and triglyceride accumulation. Apolipopreotein E-deficient lipoproteins can not induce preadipocyte to form round full-lipid adipocyte, whereas apolipoprotein E-containing lipoproteins can. This article mainly reviews the modulation of apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins in adipocyte triglyceride content.
脂肪组织中过多的能量储存导致肥胖的发生和发展,肥胖还伴有多种不良并发症,如代谢综合征、心血管疾病。众所周知,载脂蛋白E作为脂蛋白的一个组成部分,在维持血浆脂蛋白稳态中起关键作用。有趣的是,载脂蛋白E在脂肪细胞中高度表达,且与体脂量呈正相关。与野生型小鼠相比,载脂蛋白E基因敲除小鼠的脂肪量较少。此外,脂肪细胞中载脂蛋白E缺乏会导致脂蛋白内化受损和甘油三酯积累。缺乏载脂蛋白E的脂蛋白不能诱导前脂肪细胞形成圆形的充满脂质的脂肪细胞,而含有载脂蛋白E的脂蛋白则可以。本文主要综述脂肪细胞合成的载脂蛋白E以及脂蛋白携带的载脂蛋白E对脂肪细胞甘油三酯含量的调节作用。