Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
Research Center for Development Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
Int J Obes (Lond). 2024 Sep;48(9):1205-1215. doi: 10.1038/s41366-024-01549-9. Epub 2024 Jun 5.
Apolipoprotein E (APOE) is a multifunctional protein expressed by various cell types, including hepatocytes, adipocytes, immune cells of the myeloid lineage, vascular smooth muscle cells, astrocytes, etc. Initially, APOE was discovered as an arginine-rich peptide within very-low-density lipoprotein, but it was subsequently found in triglyceride-rich lipoproteins in humans and other animals, where its presence facilitates the clearance of these lipoproteins from circulation. Recent epidemiolocal studies and experimental research in mice suggest a link between ApoE and obesity. The latest findings highlight the role of endogenous adipocyte ApoE in regulating browning of white adipose tissue, beige adipocyte differentiation, thermogenesis and energy homeostasis. This review focuses on the emerging evidence showing the involvement of ApoE in the regulation of obesity and its associated metabolic diseases.
载脂蛋白 E（APOE）是一种多功能蛋白，由多种细胞类型表达，包括肝细胞、脂肪细胞、髓系免疫细胞、血管平滑肌细胞、星形胶质细胞等。最初，APOE 被发现是极低密度脂蛋白中的一种富含精氨酸的肽，但后来在人和其他动物的富含甘油三酯的脂蛋白中也发现了它的存在，它的存在有助于这些脂蛋白从循环中清除。最近的流行病学研究和小鼠实验研究表明 ApoE 与肥胖之间存在关联。最新的研究结果强调了内源性脂肪细胞 ApoE 在调节白色脂肪组织褐变、米色脂肪细胞分化、产热和能量平衡中的作用。本综述重点介绍了表明 ApoE 参与调节肥胖及其相关代谢疾病的新证据。
