Latour E, Driot J Y, Coquelet C, Bonne C
Chauvin Laboratories Research Centre, Université Montpellier, France.
Curr Eye Res. 1989 Nov;8(11):1105-10. doi: 10.3109/02713688909000035.
Anterior chamber paracentesis of the rabbit eye causes disruption of the blood-aqueous barrier, which is characterized by a rapid increase in the albumin and total protein content of the aqueous humor. Prostaglandins appear to be implicated as major mediators in this reaction, since a cyclooxygenase inhibitor, indomethacin, very efficiently prevents protein leakage. When paracentesis was performed in platelet-depleted rabbits (either by transfusion or by treatment with an antiplatelet plasma), the protein content in the aqueous humor did not rise to values observed in normal animals. These data suggest that platelets play some role in the response to paracentesis, a fact in accordance with histological results. In contrast to cyclooxygenase inhibitors, dexamethasone inhibits neither the blood-aqueous barrier breakdown nor prostanoid release from platelets. These data also indirectly indicate the possible role of platelets in triggering the paracentesis reaction in the rabbit.
兔眼前房穿刺会导致血-房水屏障破坏，其特征是房水中白蛋白和总蛋白含量迅速增加。前列腺素似乎是该反应的主要介质，因为环氧化酶抑制剂吲哚美辛能非常有效地阻止蛋白质渗漏。当在血小板减少的兔子（通过输血或用抗血小板血浆治疗）中进行穿刺时，房水中的蛋白质含量并未升至正常动物中观察到的值。这些数据表明血小板在对穿刺的反应中起一定作用，这一事实与组织学结果相符。与环氧化酶抑制剂不同，地塞米松既不抑制血-房水屏障的破坏，也不抑制血小板中前列腺素的释放。这些数据还间接表明了血小板在引发兔穿刺反应中的可能作用。
