Sato Kazuaki, Kanai Kazutaka, Ozaki Maiko, Kagawa Takaaki, Kita Mizuki, Yamashita Yohei, Nagai Noriaki, Tajima Kazuki
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan.
Faculty of Pharmacy, Kindai University, Higashi-Osaka, Osaka 577-8502, Japan.
J Vet Med Sci. 2019 Apr 16;81(4):573-576. doi: 10.1292/jvms.18-0723. Epub 2019 Feb 25.
We investigated the effects of tyrosol (Tyr) on anterior chamber paracentesis (ACP)-induced anterior uveitis in beagle dogs, as determined by protein and prostaglandin E2 (PGE2) concentrations in the aqueous humor (AH). Tyr at a dose of 100 or 200 mg/kg or 2.2 mg/kg of carprofen as a positive control was administered orally twice daily from 2.5 days before paracentesis. The initial ACP was performed in one eye of individual dogs and 0.5 ml AH was aspirated. The secondary AH was collected 60 min later. Pretreatment with 200 mg/kg of Tyr and carprofen significantly decreased aqueous protein and PGE2 concentrations compared to the control group. Overall, these findings suggested that Tyr was useful for the management of canine anterior uveitis.
我们通过检测房水中蛋白质和前列腺素E2（PGE2）的浓度，研究了酪醇（Tyr）对比格犬前房穿刺（ACP）诱导的前葡萄膜炎的影响。在穿刺前2.5天开始，每天口服给予剂量为100或200 mg/kg的Tyr或作为阳性对照的2.2 mg/kg卡洛芬，每日两次。对每只犬的一只眼睛进行初次ACP，并抽取0.5 ml房水。60分钟后收集二次房水。与对照组相比，200 mg/kg的Tyr和卡洛芬预处理显著降低了房水蛋白质和PGE2浓度。总体而言，这些发现表明Tyr可用于治疗犬前葡萄膜炎。
