从中国五个城市采集的空气细颗粒物2.5的化学和生物学特征
Chemical and biological characterization of air particulate matter 2.5, collected from five cities in China.
作者信息
Leung P Y, Wan H T, Billah M B, Cao J J, Ho K F, Wong Chris K C
机构信息
Croucher Institute for Environmental Sciences, Partner State Key Laboratory of Environmental and Biological Analysis, Department of Biology, 200 Waterloo Road, Kowloon Tong, Hong Kong Baptist University, Hong Kong, China.
Key Lab of Aerosol Science & Technology, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710075, China.
出版信息
Environ Pollut. 2014 Nov;194:188-195. doi: 10.1016/j.envpol.2014.07.032. Epub 2014 Aug 20.
Fifteen polycyclic aromatic hydrocarbons (PAHs) in PM2.5 samples collected in five different cities (Hong Kong (HK), Guangzhou (GZ), Xiamen (XM), Xi'an (XA) and Beijing (BJ)) in China in the winter 2012-13 [corrected] were analyzed by gas chromatography-mass spectrometry. The biological effects of organic extracts were assayed using the human bronchial epithelial cells BEAS-2B. All sixteen priority PAHs can be found in the PM2.5 samples of XA and BJ, but not in HK, GZ and XM, demonstrating the differential spatial source and distribution of PAHs. Our results showed that the total PAHs ranged from 3.35 to 80.45 ng/m(3) air, leading by BJ, followed by XA, XM, GZ and HK. In the cell culture study, transcript levels of pro-inflammatory cytokine interleukin-6 (IL-6), CYP1A1 and CYP1B1 were found to be induced in the treatment. The cells exposed to extracts from XA and BJ demonstrated significant migratory activities, indicating a sign of increase of tumorigenicity.
采用气相色谱 - 质谱联用仪分析了2012 - 2013年冬季在中国五个不同城市（香港（HK）、广州（GZ）、厦门（XM）、西安（XA）和北京（BJ））采集的PM2.5样本中的15种多环芳烃（PAHs）。使用人支气管上皮细胞BEAS - 2B检测有机提取物的生物学效应。在西安和北京的PM2.5样本中可检测到所有16种优先控制的PAHs，但在香港、广州和厦门的样本中未检测到，这表明PAHs存在空间来源和分布差异。我们的结果显示，空气中总PAHs含量范围为3.35至80.45 ng/m³，北京最高，其次是西安、厦门、广州和香港。在细胞培养研究中，发现促炎细胞因子白细胞介素 - 6（IL - 6）、CYP1A1和CYP1B1的转录水平在处理过程中被诱导。暴露于西安和北京提取物的细胞表现出显著的迁移活性，表明有致癌性增加的迹象。
Zotero 插件