The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Key Lab of Aerosol Chemistry & Physics, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China.
Environ Sci Pollut Res Int. 2019 Nov;26(31):31913-31923. doi: 10.1007/s11356-019-06323-3. Epub 2019 Sep 5.
The chemical and cytotoxicity properties of fine particulate matter (PM) at indoor and outdoor environment were characterized in Xi'an, China. The mass concentrations of PM in urban areas (93.2996.13 μg m for indoor and 124.37154.52 μg m for outdoor) were higher than suburban (68.40 μg m for indoor and 96.18 μg m for outdoor). The PM concentrations from outdoor environment due to fossil fuel combustion were higher than indoor environment. An indoor environment without central heating demonstrated higher organic carbon-to-elemental carbon (OC / EC) ratios and n-alkanes values that potentially attributed to residential coal combustion activities. The cell viability of human epithelial lung cells showed dose-dependent decrease, while nitric oxide (NO) and oxidative potential showed dose-dependent increase under exposure to PM. The variations of bioreactivities could be possibly related to different chemical components from different sources. Moderate (0.4 < R < 0.6) to strong (R > 0.6) correlations were observed between bioreactivities and elemental carbon (EC)/secondary aerosols (NO, SO, and NH)/heavy metals (Ni, Cu, and Pb). The findings suggest PM is associated with particle induced oxidative potential, which are further responsible for respiratory diseases under chronic exposure.
在中国西安，研究了室内和室外环境中细颗粒物（PM）的化学性质和细胞毒性。城市地区（室内 93.2996.13μg/m，室外 124.37154.52μg/m）的 PM 质量浓度高于郊区（室内 68.40μg/m，室外 96.18μg/m）。由于化石燃料燃烧导致的室外环境 PM 浓度高于室内环境。没有集中供暖的室内环境表现出更高的有机碳-元素碳（OC/EC）比值和正构烷烃值，这可能归因于居民煤炭燃烧活动。暴露于 PM 下，人上皮肺细胞的细胞活力表现出剂量依赖性下降，而一氧化氮（NO）和氧化电势则表现出剂量依赖性增加。生物活性的变化可能与不同来源的不同化学物质有关。在生物活性和元素碳（EC）/二次气溶胶（NO、SO 和 NH）/重金属（Ni、Cu 和 Pb）之间观察到中等（0.4<R<0.6）到强（R>0.6）相关性。研究结果表明，PM 与颗粒诱导的氧化电势有关，这是导致慢性暴露下呼吸道疾病的原因。
