Trieu Nelson, Eslick Guy D
The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia.
The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia.
Int J Cardiol. 2014 Oct 20;176(3):687-95. doi: 10.1016/j.ijcard.2014.07.079. Epub 2014 Aug 1.
Alopecia has been associated with an increased risk of coronary heart disease as well as the following risk factors for cardiovascular disease: hyperinsulinaemia, insulin resistance, metabolic syndrome, dyslipidaemia, and hypertension. We performed a meta-analysis to quantitatively determine the level of risk of coronary heart disease and risk factors in individuals with alopecia.
A systematic literature search was conducted using several databases. We calculated pooled odds ratios and 95% confidence intervals using a random effects model.
In total, 31 studies comprising 29,254 participants with alopecia were eligible for the meta-analysis and showed that alopecia is associated with an increased risk of coronary heart disease (OR 1.22, 95% CI: 1.07-1.39), hyperinsulinaemia (OR 1.97, 95% CI: 1.20-3.21), insulin resistance (OR 4.88, 95% CI: 2.05-11.64), and metabolic syndrome (OR 4.49, 95% CI: 2.36-8.53). Individuals with alopecia were also shown to be more likely compared to those without alopecia to have higher serum cholesterol levels (OR 1.60, 95% CI: 1.17-2.21), higher serum triglyceride levels (OR 2.07, 95% CI: 1.32-3.25), higher systolic blood pressures (OR 1.73, 95% CI: 1.29-2.33), and higher diastolic blood pressures (OR 1.59, 95% CI: 1.16-2.18).
Alopecia is associated with an increased risk of coronary heart disease, and there appears to be a dose-response relationship with degree of baldness whereby the greater the severity of alopecia, the greater the risk of coronary heart disease. Alopecia is also associated with an increased risk of hypertension, hyperinsulinaemia, insulin resistance, metabolic syndrome, and having elevated serum total cholesterol and triglyceride levels.
脱发与冠心病风险增加以及心血管疾病的以下风险因素相关：高胰岛素血症、胰岛素抵抗、代谢综合征、血脂异常和高血压。我们进行了一项荟萃分析，以定量确定脱发个体患冠心病和风险因素的风险水平。
使用多个数据库进行系统的文献检索。我们使用随机效应模型计算合并比值比和95%置信区间。
总共有31项研究，包括29254名脱发参与者，符合荟萃分析的条件，结果显示脱发与冠心病风险增加相关（比值比1.22，95%置信区间：1.07 - 1.39）、高胰岛素血症（比值比1.97，95%置信区间：1.20 - 3.21）、胰岛素抵抗（比值比4.88，95%置信区间：2.05 - 11.64）和代谢综合征（比值比4.49，95%置信区间：2.36 - 8.53）。与无脱发者相比，脱发个体血清胆固醇水平更高（比值比1.60，95%置信区间：1.17 - 2.21）、血清甘油三酯水平更高（比值比2.07，95%置信区间：1.32 - 3.25）、收缩压更高（比值比1.73，95%置信区间：1.29 - 2.33）和舒张压更高（比值比1.59，95%置信区间：1.16 - 2.18）的可能性也更高。
脱发与冠心病风险增加相关，并且似乎与脱发程度存在剂量反应关系，即脱发越严重，冠心病风险越高。脱发还与高血压、高胰岛素血症、胰岛素抵抗、代谢综合征以及血清总胆固醇和甘油三酯水平升高的风险增加相关。
