TSP-1-696 C/T基因多态性对膀胱癌易感性及临床病理特征的影响。
Effects of TSP-1-696 C/T polymorphism on bladder cancer susceptibility and clinicopathologic features.
作者信息
Gu Jinbao, Tao Jun, Yang Xiao, Li Pengchao, Yang Xuejian, Qin Chao, Cao Qiang, Cai Hongzhou, Zhang Zhengdong, Wang Meilin, Gu Min, Lu Qiang, Yin Changjun
机构信息
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cancer Center of Nanjing Medical University, Department of Molecular and Genetic Toxicology, Nanjing Medical University, Nanjing, China.
出版信息
Cancer Genet. 2014 Jun;207(6):247-52. doi: 10.1016/j.cancergen.2014.06.023. Epub 2014 Jun 26.
Thrombospondin-1 (TSP-1) is a glycoprotein that plays a major role in bladder cancer. We investigated the relationship between the distribution of the TSP-1 -696 C/T polymorphism (rs2664139) and the clinical features of bladder cancer. TaqMan assay was used to determine the genotype among the 609 cases and 670 controls in a Chinese population. Logistic regression was used to assess the association between the polymorphism and bladder cancer risk. Compared with the CT/TT genotypes, the CC genotype was associated with a significantly increased risk of bladder cancer (adjusted odds ratio [OR] 1.43, 95% CI 1.01-2.04), which was more prominent among the male participants (OR 1.82, 95% CI 1.20-2.76). The polymorphism was associated with a higher risk of developing grade 3 (OR 1.84, 95% CI 1.00-3.36), multiple-tumor (OR 1.81, 95% CI 1.08-3.02), and large-tumor (OR 1.94, 95% CI 1.22-3.10) bladder cancers. These observations suggest that the TSP-1 -696 C/T polymorphism may contribute to bladder cancer susceptibility in the Chinese population.
血小板反应蛋白-1（TSP-1）是一种糖蛋白，在膀胱癌中起主要作用。我们研究了TSP-1 -696 C/T多态性（rs2664139）的分布与膀胱癌临床特征之间的关系。采用TaqMan分析法确定中国人群中609例病例和670例对照的基因型。使用逻辑回归评估该多态性与膀胱癌风险之间的关联。与CT/TT基因型相比，CC基因型与膀胱癌风险显著增加相关（调整优势比[OR] 1.43，95%置信区间1.01-2.04），在男性参与者中更为显著（OR 1.82，95%置信区间1.20-2.76）。该多态性与3级膀胱癌（OR 1.84，95%置信区间1.00-3.36）、多肿瘤膀胱癌（OR 1.81，95%置信区间1.08-3.02）和大肿瘤膀胱癌（OR 1.94，95%置信区间1.22-3.10）的发生风险较高相关。这些观察结果表明，TSP-1 -696 C/T多态性可能与中国人群的膀胱癌易感性有关。
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