血小板反应蛋白-1（THBS1）
THBS1 (thrombospondin-1).
作者信息
Isenberg Jeffrey S, Roberts David D
机构信息
Radiation Control Technologies, Inc., Loudonville, NY, USA.
Biochemical Pathology Section, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892, USA.
出版信息
Atlas Genet Cytogenet Oncol Haematol. 2020;24(8):291-299. doi: 10.4267/2042/70774.
Abstract
Thrombospondins are encoded in vertebrates by a family of genes. is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncogenes and promoter hypermethylation. Consequently, thrombospondin-1 expression is frequently lost during oncogenesis and is correlated with a poor prognosis for some cancers. Thrombospondin-1 is a secreted protein that acts in the tumor microenvironment to inhibit angiogenesis, regulate antitumor immunity, stimulate tumor cell migration, and regulate the activities of extracellular proteases and growth factors. Differential effects of thrombospondin-1 on the sensitivity of normal versus malignant cells to ischemic and genotoxic stress also regulate the responses to tumors to therapeutic radiation and chemotherapy.
摘要
血小板反应蛋白在脊椎动物中由一个基因家族编码。在大多数癌症中它很少发生突变，但其表达受到多种肿瘤抑制基因的正向调控，并受到激活的癌基因和启动子高甲基化的负向调控。因此，血小板反应蛋白-1的表达在肿瘤发生过程中经常缺失，并且与某些癌症的不良预后相关。血小板反应蛋白-1是一种分泌蛋白，在肿瘤微环境中发挥作用，抑制血管生成、调节抗肿瘤免疫、刺激肿瘤细胞迁移，并调节细胞外蛋白酶和生长因子的活性。血小板反应蛋白-1对正常细胞与恶性细胞对缺血和基因毒性应激敏感性的不同影响也调节了肿瘤对放射治疗和化疗的反应。
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