Rådmark Olof, Werz Oliver, Steinhilber Dieter, Samuelsson Bengt
Dept of Medical Biochemistry and Biophysics, Div. of Chemistry II, Karolinska Institutet, Sweden.
Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University Jena, Germany.
Biochim Biophys Acta. 2015 Apr;1851(4):331-9. doi: 10.1016/j.bbalip.2014.08.012. Epub 2014 Aug 22.
5-Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX biochemistry including 5-LOX interacting proteins and regulation of enzyme activity. LTs function in normal host defense, and have roles in many disease states where acute or chronic inflammation is part of the pathophysiology, as briefly summarized at the end of this chapter. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".
5-脂氧合酶（5-LOX）催化白三烯（LTs）生物合成中的两个步骤，白三烯是由花生四烯酸衍生而来的炎症脂质介质。在本综述中，我们重点关注5-LOX生物化学，包括5-LOX相互作用蛋白和酶活性调节。白三烯在正常宿主防御中发挥作用，并且在许多疾病状态中起作用，其中急性或慢性炎症是病理生理学的一部分，本章末尾对此进行了简要总结。本文是名为“多不饱和脂肪酸的氧化代谢：分析与生物学意义”的特刊的一部分。
