Department of Physiology, Queen's University, Kingston, ON K7L 3N6, Canada.
Sci Transl Med. 2011 Jan 19;3(66):66ps3. doi: 10.1126/scitranslmed.3002040.
Leukotrienes are arachidonic acid-derived lipid mediators of inflammation. The initial catalytic step in the formation of leukotrienes is catalyzed by 5-lipoxygenase (5-LOX) in conjunction with its activating partner protein FLAP. The long-awaited crystal structure of 5-LOX--reported in a recent issue of Science--should lead to novel, purpose-designed inhibitors for the treatment of asthma and for probing leukotriene involvement in cardiovascular disease and cancer.
白三烯是花生四烯酸衍生的炎症脂质介质。白三烯形成的初始催化步骤由 5-脂氧合酶（5-LOX）与激活其的伴侣蛋白 FLAP 共同催化。Science 杂志最近报道了期待已久的 5-LOX 晶体结构，这将为治疗哮喘以及探索白三烯在心血管疾病和癌症中的作用提供新的、有针对性的抑制剂。
