Al Hamzi Hanan, Alhaymouni Badrieh, Al Shaikh Ahmad, Al-Mayouf Sulaiman M
Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Clin Exp Rheumatol. 2014 Nov-Dec;32(6):984-8. Epub 2014 Aug 15.
We aimed to describe the social, educational, employment and long-term clinical outcomes of adults with childhood-onset systemic lupus erythematosus (SLE) in a Saudi cohort.
All adult patients with childhood-onset SLE who were treated and had regular follow-up between 1990 and 2013 at King Faisal Specialist Hospital and Research Centre (KFSH-RC), Riyadh were included. The long-term outcome measures comprised SLE Disease Activity and Damage Indices at the last follow-up visit and death related to SLE. Social, educational and employment history were obtained via personal or phone interviews.
Forty-eight patients (45 female) were included, whose mean age was 23.6±4 years and mean disease duration 15±4 years. At the last follow-up visit, 24 (50%) patients were found to have active disease with mean of accrual damage index of 2 (0-7). Forty patients (83%) had renal involvement, 7 (15%) of them progressed to end stage renal disease, 5 patients underwent renal transplant, 2 failed the transplant and are currently on haemodialysis. Sixteen patients had central nervous system involvement in the form of seizure disorder (6 patients), chorea (3 patients) and cerebrovascular accident (3 patients). Forty-three patients completed high school and 21 joined a college. Six patients were in employment. Eight patients got married and 5 of them had children. There were 3 deaths related to SLE (6.25%), mainly due to infection.
Our cohort indicates that the outcome of adult Saudi patients with childhood-onset SLE was satisfactory and comparable to earlier reports.
我们旨在描述沙特一个队列中患有儿童期起病的系统性红斑狼疮（SLE）的成年人的社会、教育、就业及长期临床结局。
纳入所有1990年至2013年期间在利雅得法赫德国王专科医院及研究中心（KFSH-RC）接受治疗并定期随访的儿童期起病的SLE成年患者。长期结局指标包括最后一次随访时的SLE疾病活动度和损伤指数以及与SLE相关的死亡情况。通过个人访谈或电话访谈获取社会、教育和就业史。
纳入48例患者（45例女性），平均年龄23.6±4岁，平均病程15±4年。在最后一次随访时，发现24例（50%）患者有活动性疾病，累积损伤指数平均为2（0-7）。40例患者（83%）有肾脏受累，其中7例（15%）进展至终末期肾病，5例患者接受了肾移植，2例移植失败，目前正在接受血液透析。16例患者有中枢神经系统受累，表现为癫痫发作（6例）、舞蹈症（3例）和脑血管意外（3例）。43例患者完成了高中学业，21例进入大学。6例患者就业。8例患者结婚，其中5例育有子女。有3例与SLE相关的死亡（6.25%），主要原因是感染。
我们的队列表明，沙特儿童期起病的SLE成年患者的结局令人满意，与早期报告相当。
