Iwata S, Sato Y, Tojo M, Kusumoto Y, Shiro H, Akita H, Nanri S, Oikawa T, Osano M, Kusano S
Department of Pediatrics, School of Medicine, Keio University.
Jpn J Antibiot. 1989 Dec;42(12):2714-9.
Pharmacokinetics and clinical studies on cefsulodin (CFS) were conducted in neonates. 1. MIC's of CFS, sulbenicillin and gentamicin (GM) were determined using 7 strains of Pseudomonas aeruginosa clinically isolated from neonates and maintained as stock cultures. CFS was found to be nearly as active as GM. 2. When CFS 20 mg/kg was administered to a 12-day-old neonate by intravenous bolus injection, serum concentrations were 8.7 micrograms/ml before administration and 51.7 micrograms/ml at 30 minutes, 44.4 micrograms/ml at 1 hour, 38.6 micrograms/ml at 2 hours and 11.1 micrograms/ml at 6 hours after administration. The half-life was 2.5 hours. 3. CFS was administered alone or combination with other drugs to 3 neonates. The drug was clinically effective in 2 cases and slightly effective in another. Bacteriologically, one case was rated as decreased, another as replaced, and the remaining one as unchanged. 4. Neither side effects nor abnormal laboratory values attributable to CFS were found.
对头孢磺啶（CFS）进行了新生儿药代动力学和临床研究。1. 使用从新生儿临床分离并作为储备培养物保存的7株铜绿假单胞菌测定了CFS、磺苄西林和庆大霉素（GM）的最低抑菌浓度（MIC）。发现CFS的活性与GM相近。2. 对一名12日龄新生儿静脉推注给予20mg/kg的CFS后，给药前血清浓度为8.7μg/ml，给药后30分钟为51.7μg/ml，1小时为44.4μg/ml，2小时为38.6μg/ml，6小时为11.1μg/ml。半衰期为2.5小时。3. 对3名新生儿单独或与其他药物联合给予CFS。该药在2例中临床有效，在另一例中效果稍差。从细菌学角度看，1例评级为细菌数量减少，1例为被替代，其余1例无变化。4. 未发现归因于CFS的副作用或实验室异常值。
