健康成年人呼吸点补偿的测定：无创近红外光谱技术能有所帮助吗？
Determination of respiratory point compensation in healthy adults: Can non-invasive near-infrared spectroscopy help?
作者信息
Fontana Federico Y, Keir Daniel A, Bellotti Cecilia, De Roia Gabriela F, Murias Juan M, Pogliaghi Silvia
机构信息
Department of Neurological and Movement Sciences, University of Verona, Italy.
Canadian Center for Activity and Aging, School of Kinesiology, University of Western Ontario, Canada.
出版信息
J Sci Med Sport. 2015 Sep;18(5):590-5. doi: 10.1016/j.jsams.2014.07.016. Epub 2014 Aug 7.
OBJECTIVES
We tested the hypothesis that the respiratory compensation point can be accurately determined in healthy participants during incremental cycling exercise using non-invasive near-infrared spectroscopy-derived measures of deoxygenated hemoglobin (deoxyHb).
DESIGN
Validation study.
METHODS
118 healthy men (average age 47 ± 19 yrs, range 20-79 yrs) performed an incremental cycling test to exhaustion. Breath-by-breath pulmonary oxygen uptake (VO2) and other ventilatory and gas exchange variables were measured and used to determine respiratory compensation point. Vastus lateralis deoxyHb was monitored using a frequency domain multi-distance system near-infrared spectroscopy device and deoxyHb data were modeled with a piece-wise double-linear function from which the deoxyHb deflection point (deoxyHbDP) was determined. The absolute (L min(-1)) and relative (% maximal VO2 [VO 2max]) VO2 values associated with the respiratory compensation point and deoxyHbDP were determined for each individual.
RESULTS
DeoxyHb increased as a function of exercise intensity up to a point (deoxyHbDP) after which the signal displayed a "near-plateau". The deoxyHbDP corresponded to a VO2 of 2.25 ± 0.69 L min(-1) (74 ± 12% VO 2max) which was not significantly different from the VO2 at respiratory compensation point (2.28 ± 0.70 L min(-1) and 74 ± 10% VO 2max, p < 0.05). Both indices were highly correlated (r(2) = 0.86) and Bland Altman analyses confirmed a non-significant bias for VO2 (-0.024 L min(-1)) concomitant with a small imprecision of 0.26 L min(-1).
CONCLUSIONS
During incremental cycling exercise, the VO2 associated with the onset of a plateau in near-infrared spectroscopy-derived deoxyHb occurs in coincidence with the VO2 at respiratory compensation point suggesting that respiratory compensation point can be accurately estimated, non-invasively, using near-infrared spectroscopy-derived deoxyHb in alternative to the use of ventilatory-based techniques.
目的
我们检验了这样一个假设，即通过使用无创近红外光谱法测量脱氧血红蛋白（deoxyHb），在健康受试者进行递增式自行车运动期间，可以准确测定呼吸补偿点。
设计
验证性研究。
方法
118名健康男性（平均年龄47±19岁，范围20 - 79岁）进行递增式自行车测试直至力竭。逐次呼吸测量肺摄氧量（VO2）以及其他通气和气体交换变量，并用于确定呼吸补偿点。使用频域多距离系统近红外光谱设备监测股外侧肌的脱氧血红蛋白，并对脱氧血红蛋白数据采用分段双线性函数进行建模，从中确定脱氧血红蛋白偏转点（deoxyHbDP）。为每个个体确定与呼吸补偿点和脱氧血红蛋白偏转点相关的绝对（L min⁻¹）和相对（%最大VO2 [VO₂max]）VO2值。
结果
随着运动强度增加，脱氧血红蛋白增加，直至达到一个点（脱氧血红蛋白偏转点），此后信号呈现“近似平台期”。脱氧血红蛋白偏转点对应的VO2为2.25±0.69 L min⁻¹（74±12% VO₂max），这与呼吸补偿点时的VO2（2.28±0.70 L min⁻¹和74±10% VO₂max）无显著差异（p < 0.05）。两个指标高度相关（r² = 0. eighty-six），Bland Altman分析证实VO2的偏差不显著（-0.024 L min⁻¹），同时不精密度较小，为0.26 L min⁻¹。
结论
在递增式自行车运动期间，近红外光谱法测量的脱氧血红蛋白出现平台期起始时的VO2与呼吸补偿点时的VO2一致，这表明使用近红外光谱法测量的脱氧血红蛋白可替代基于通气的技术，无创地准确估计呼吸补偿点。
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