Aubert G, Puech C, Lucht F, Loboguerrero M, Denis M, Dorche G
Service de Bactériologie, Hôpital de Bellevue, Universitaire Saint-Etienne, France.
Pathol Biol (Paris). 1989 Oct;37(8):881-7.
The minimum inhibitory concentrations (MIC) of 5 fluoroquinolones, fleroxacin (FLE), ciprofloxacin (CIP), ofloxacin (OFL), enoxacin (ENO) and norfloxacin (NOR) have been determined by the agar dilution method towards 140 strains of Pseudomonas aeruginosa (Pa) and 146 Enterobacteriaceae showing different sensitivities to pefloxacin (PEF). The strains were isolated in 1988 at the Bellevue Hospital. The modal MIC is 0.12 for CIP, 0.25 for NOR, 0.5 for OFL, and 1 for FLE and ENO when used on Pa strains which are sensitive to PEF (n = 35) (MIC less than or equal to 1mg/1). The modal MIC is 0.25 - 0.5 for CIP, 0.5 for NOR, 1 for OFL and ENO, and 2 for FLE when used on Pa strains which are of intermediate sensitivity to PEF (n = 70) (1 less than MIC less than or equal to 4). The modal MIC is 2 for CIP, 8 for NOR and OFL, 8 - 16 for ENO, and 32 for FLE when used on Pa strains which are resistant to PEF (n = 35) (MIC greater than 4). The modal MIC is 0.015 for CIP, 0.06 for OFL, 0.12 for FLE, NOR and ENO when used on Escherichia coli strains which are sensitive to PEF (n = 47). The modal MIC is 0.5 for CIP, 1 for OFL and NOR, and 2 FLE and ENO, when used on Escherichia coli strains which are of intermediate sensitivity to PEF (n = 38). The modal MIC is 1 for CIP, 4 for OFL and NOR, 16 for FLE, and 32 for ENO when used on E coli strains which are resistant to PEF (n = 15). The 26 Serratia marcescens and 20 Citrobacter with MIC greater than or equal to 8 for PEF all have MICs greater than 1 and modal MICs greater than or equal to 4 for all the fluoroquinolones studied. CIP always showed greater activity than the other quinolones whatever the sensitivity shown towards PEF.
采用琼脂稀释法测定了5种氟喹诺酮类药物，即氟罗沙星（FLE）、环丙沙星（CIP）、氧氟沙星（OFL）、依诺沙星（ENO）和诺氟沙星（NOR）对140株铜绿假单胞菌（Pa）和146株肠杆菌科细菌的最低抑菌浓度（MIC），这些菌株对培氟沙星（PEF）表现出不同的敏感性。这些菌株于1988年在贝尔维尤医院分离得到。当用于对PEF敏感的Pa菌株（n = 35）（MIC小于或等于1mg/1）时，CIP的模式MIC为0.12，NOR为0.25，OFL为0.5，FLE和ENO为1。当用于对PEF中度敏感的Pa菌株（n = 70）（1＜MIC≤4）时，CIP的模式MIC为0.25 - 0.5，NOR为0.5，OFL和ENO为1，FLE为2。当用于对PEF耐药的Pa菌株（n = 35）（MIC＞4）时，CIP的模式MIC为2，NOR和OFL为8，ENO为8 - 16，FLE为32。当用于对PEF敏感的大肠埃希菌菌株（n = 47）时，CIP的模式MIC为0.015，OFL为0.06，FLE、NOR和ENO为0.12。当用于对PEF中度敏感的大肠埃希菌菌株（n = 38）时，CIP的模式MIC为0.5，OFL和NOR为1，FLE和ENO为2。当用于对PEF耐药的大肠埃希菌菌株（n = 15）时，CIP的模式MIC为1，OFL和NOR为4，FLE为16，ENO为32。对PEF的MIC大于或等于8的26株粘质沙雷菌和20株柠檬酸杆菌，对所有研究的氟喹诺酮类药物的MIC均大于1，模式MIC大于或等于4。无论对PEF表现出何种敏感性，CIP始终比其他喹诺酮类药物表现出更强的活性。
