Yue W J, Xiao S H, Mei J Y
Zhongguo Yao Li Xue Bao. 1989 Sep;10(5):476-9.
Rabbits were infected with 48-52, 198-202 and 498-502 cercariae of Schistosoma japonicum and treated ig with single doses of praziquantel (40 mg/kg) 4 and 8 wk post infection. The worm reduction rates of the 8 wk groups were 87.9, 92.2 and 97%, respectively. These values were significantly higher than 48.5, 52.3 and 58.6% for the corresponding 4 wk groups. The serum antibody titres of the 8 wk post infection rabbits were apparently higher than those of the 4 wk rabbits. Meanwhile, for the same duration of infection, the specific antibody levels in the heavy worm burden groups were also higher than those in the light worm burden groups. The results obtained in the mice infected with S. japonicum at different intensities and treated ig with single doses of praziquantel at 300 mg/kg at different durations were similar to the results in the rabbits. The correlation between efficacy and specific antibody level was confirmed by calculating the coefficient of correlation with r values of 0.454-0.983 (P less than 0.01). The results also indicated that heavy infections with S. japonicum were still more responsive to praziquantel treatment. In addition, the effect of praziquantel on worms was closely related to the specific antibody response in the host.
用48 - 52条、198 - 202条和498 - 502条日本血吸虫尾蚴感染兔子，并在感染后4周和8周分别单次ig给予吡喹酮（40 mg/kg）。8周组的减虫率分别为87.9%、92.2%和97%。这些值显著高于相应4周组的48.5%、52.3%和58.6%。感染后8周兔子的血清抗体滴度明显高于4周兔子。同时，在相同感染持续时间内，重虫负荷组的特异性抗体水平也高于轻虫负荷组。以不同强度感染日本血吸虫并在不同时间以300 mg/kg单次ig给予吡喹酮的小鼠所获得的结果与兔子的结果相似。通过计算相关系数，r值为0.454 - 0.983（P小于0.01），证实了疗效与特异性抗体水平之间的相关性。结果还表明，重度日本血吸虫感染对吡喹酮治疗仍更敏感。此外，吡喹酮对虫体的作用与宿主中的特异性抗体反应密切相关。
