Xiao S H, Yang Y Q, Zhang C W, You J Q
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, China.
Zhongguo Yao Li Xue Bao. 1996 Mar;17(2):167-70.
To study the histopathological change of the liver of the hosts treated with artemether (Art) or praziquantel (Pra) in early stage after infection with Schistosoma japonicum cercariae.
Dogs infected once with schistosome cercariae were treated ig with Art 10 mg.kg-1 or Art capsule (ArtC) 15 mg.kg-1 on d 7, or praziquantel (Pra) 30-40 mg.kg-1 on d 21 after infection, followed by the repeated dosing once every 1 or 2 wk for 2-4 times. In rabbits, infected with 48-52 schistosome cercariae once every other day for 5 times, were treated ig with Art 10 mg.kg-1 or Pra 30 mg.kg-1 was started on d 7 or on d 21 after the first infection, followed by the repeated dosing every 1 or 2 wk for 2-3 times.
After above mentioned dogs or rabbits were treated ig with Art, ArtC or Pra, the female worm reduction rates were 92.1%-100%. Histopathological examination showed that the reduction rates of total granuloma in the liver sections of the dogs and rabbits were 70.9%-97.3% and 76.5%-97.4%, respectively. Meantime, the structure of the hepatic lobules was normal with normal arrangement of the liver bundle.
Early treatment with Art or Pra exhibited a promising effect of protection of the liver of the dogs and rabbits infected with schistosome cercariae. Early treatment of infection with schistosome cercariae kills the Female worms before oviposition. Thus, the host will be protected from the damage caused by schistosome eggs. Promising results were obtained when mice and rabbits received an early treatment with artemether (Art) or praziquantel (Pra). This work was to study the liver infected with cercariae and treated by intragastric gavage (ig) with Art, Art capsule (ArtC) or Pra in early stage after infection.
研究感染日本血吸虫尾蚴早期用蒿甲醚（Art）或吡喹酮（Pra）治疗的宿主肝脏的组织病理学变化。
单次感染血吸虫尾蚴的犬在感染后第7天灌胃给予蒿甲醚10mg·kg-1或蒿甲醚胶囊（ArtC）15mg·kg-1，或在感染后第21天给予吡喹酮（Pra）30 - 40mg·kg-1，随后每隔1或2周重复给药1次，共给药2 - 4次。家兔每隔1天感染48 - 52条血吸虫尾蚴，共感染5次，在首次感染后第7天或第21天开始灌胃给予蒿甲醚10mg·kg-1或吡喹酮30mg·kg-1，随后每隔1或2周重复给药，共给药2 - 3次。
上述犬或家兔经蒿甲醚、蒿甲醚胶囊或吡喹酮灌胃治疗后，雌虫减少率为92.1% - 100%。组织病理学检查显示，犬和家兔肝脏切片中总肉芽肿减少率分别为70.9% - 97.3%和76.5% - 97.4%。同时，肝小叶结构正常，肝索排列整齐。
早期用蒿甲醚或吡喹酮治疗对感染血吸虫尾蚴的犬和家兔肝脏具有良好的保护作用。早期治疗血吸虫尾蚴感染可在雌虫产卵前将其杀死。因此，宿主可免受血吸虫卵所致损害。小鼠和家兔早期用蒿甲醚（Art）或吡喹酮（Pra）治疗取得了良好效果。本研究旨在探讨感染尾蚴后早期经胃内灌胃（ig）给予蒿甲醚、蒿甲醚胶囊（ArtC）或吡喹酮对肝脏的影响。
