Olivier A, Riquet W, Poitevin C, Charleux H, Mignon M, Vatier J
Ann Chir. 1989;43(10):829-37.
Different surgical models are used in the dog for studying gastric secretion: gastric fistula, denervated Heidenhain pouch, innervated Amdrup pouch and cervical esophagostomy. The surgical procedures are described as well as the care and the monitoring allowing long-term survival of the animals. The association of gastric fistula - Heidenhain pouch has been assessed 30 times and 8 times with cervical esophagostomy. The death-rate was been 7% and the morbidity 24%. Three dogs were provided with an Amdrup pouch. Calibration of the animals allowed the acid and pepsin secreting dose-response to be platted and translation according to lineweaver-Burk or Dowd and Riggs is used to calculate the efficient dose (ED 50) and the maximal response (maxR). Pharmacological or physiological effects might be analyzed in regard to the modification of these parameters in response to a pharmacological agonist or antagonist substance. Some physiological studies could be made using sham-feeding on dogs fitted with a cervical esophagostomy.
胃瘘、去神经支配的海登海因袋、有神经支配的阿姆德鲁普袋和颈段食管造口术。文中描述了手术过程以及为使动物长期存活所采取的护理和监测措施。胃瘘与海登海因袋联合使用进行了30次评估，与颈段食管造口术联合使用进行了8次评估。死亡率为7%，发病率为24%。三只犬配备了阿姆德鲁普袋。对动物进行校准后，绘制酸和胃蛋白酶分泌的剂量反应曲线，并根据林-伯克法或多德-里格斯法进行转换，以计算有效剂量（ED50）和最大反应（maxR）。可以根据这些参数在药理学激动剂或拮抗剂物质作用下的变化来分析药理学或生理学效应。对于装有颈段食管造口术的犬，可通过假饲进行一些生理学研究。
