7岁前的夜间干咳与学龄期哮喘相关。

Nocturnal dry cough in the first 7 years of life is associated with asthma at school age.

作者信息

Boudewijn Ilse M, Savenije Olga E M, Koppelman Gerard H, Wijga Alet H, Smit Henriëtte A, de Jongste Johan C, Gehring Ulrike, Postma Dirkje S, Kerkhof Marjan

机构信息

University of Groningen, University Medical Center Groningen, Department of Epidemiology, GRIAC Research Institute, Groningen, The Netherlands.

University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine, GRIAC Research Institute, Groningen, The Netherlands.

出版信息

Pediatr Pulmonol. 2015 Sep;50(9):848-55. doi: 10.1002/ppul.23092. Epub 2014 Aug 26.

DOI:10.1002/ppul.23092

PMID:25158300

Abstract

BACKGROUND

Childhood wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of wheeze.

METHODS

Data of 3,252 children from the PIAMA birth cohort were studied. Parents reported the presence of nocturnal dry cough, wheeze, and doctor-diagnosed asthma in the past 12 months yearly, from birth up to the age of 8 years.

RESULTS

Nocturnal dry cough without wheeze was significantly associated with doctor-diagnosed asthma at age 8, except for age 1 (range of Relative Risks (RR) at ages 2-7: 1.8 (age 5) - 7.1 (age 7), all P-values <0.048). As expected, wheeze without nocturnal dry cough was strongly associated with doctor-diagnosed asthma at age 8 (range of RR: 2.0 (age 1) - 22.2 (age 7), all P-values <0.003). Of interest, nocturnal dry cough with wheeze showed the strongest association with doctor-diagnosed asthma at age 8 (range of RR: 3.7 (age 1) - 26.0 (age 7), all P-values <0.001). The relative excess risk of asthma at age 8 due to interaction of nocturnal dry cough with wheeze at age 1 year was 1.8 (0.1-3.6, P < 0.01).

CONCLUSION

Nocturnal dry cough and wheeze in early childhood are both independently associated with asthma at school age. The presence of both nocturnal dry cough and wheeze at age 1 almost doubles the risk of asthma at age 8 compared to wheeze alone.

摘要

背景

儿童喘息是哮喘的一个重要且广为人知的危险因素，但关于夜间干咳的作用却知之甚少。我们调查了1至7岁时的夜间干咳与8岁时医生诊断的哮喘之间的关联，包括有喘息和无喘息的情况。

方法

对PIAMA出生队列中的3252名儿童的数据进行了研究。父母每年报告过去12个月内孩子是否有夜间干咳、喘息以及医生诊断的哮喘情况，从出生到8岁。

结果

无喘息的夜间干咳与8岁时医生诊断的哮喘显著相关，但1岁时除外（2至7岁相对风险（RR）范围：5岁时为1.8 - 7岁时为7.1，所有P值<0.048）。正如预期的那样，无夜间干咳的喘息与8岁时医生诊断的哮喘密切相关（RR范围：1岁时为2.0 - 7岁时为22.2，所有P值<0.003）。有趣的是，伴有喘息的夜间干咳与8岁时医生诊断的哮喘关联最强（RR范围：1岁时为3.7 - 7岁时为26.0，所有P值<0.001）。1岁时夜间干咳与喘息相互作用导致8岁时哮喘的相对超额风险为1.8（0.1 - 3.6，P < 0.01）。