Banovec M, Planinsek O, Vrecer F
Pharmazie. 2014 Aug;69(8):595-601.
The influence of different additives on the mechanical properties of hydroxypropyl methylcellulose (HPMC) free films was studied using tensile testing. Free films were prepared using the cast method and sliced into bands, and their tensile strength and maximal elongation at break was measured. The results showed that the addition of PEG 400 and polysorbate 80 into the coating formulation had the most influence on the films' mechanical properties compared to the HPMC film used as a control. Tablet cores composed of microcrystalline cellulose and lactose with and without Mg stearate and compressed at three different compression forces were tested for wettability with coating formulations containing PEG 400 and polysorbate 80. For formulations with no Mg stearate added, the contact angle decreased with increasing core hardness and it also coincided with greater adhesion force of the coating. The addition of Mg stearate in the core led to reduced adhesion of the film coating with PEG 400, whereas the influence on the adhesion force of the film coating containing polysorbate 80 was negligible. The results also show that the adhesion force, regardless of the tablet core formulation, is highest at medium core hardness.
采用拉伸试验研究了不同添加剂对羟丙基甲基纤维素（HPMC）游离膜力学性能的影响。采用流延法制备游离膜并切成条带，测量其拉伸强度和最大断裂伸长率。结果表明，与用作对照的HPMC膜相比，在包衣配方中添加聚乙二醇400（PEG 400）和吐温80对膜的力学性能影响最大。对由微晶纤维素和乳糖组成、添加和不添加硬脂酸镁并在三种不同压力下压制的片芯，用含有PEG 400和吐温80的包衣配方测试其润湿性。对于未添加硬脂酸镁的配方，接触角随片芯硬度增加而减小，这也与包衣的更大附着力相一致。在片芯中添加硬脂酸镁会导致含PEG 400的薄膜包衣的附着力降低，而对含吐温80的薄膜包衣的附着力影响可忽略不计。结果还表明，无论片芯配方如何，附着力在中等片芯硬度时最高。
