Fisher D G, Rowe R C
J Pharm Pharmacol. 1976 Dec;28(12):886-9. doi: 10.1111/j.2042-7158.1976.tb04086.x.
The strength of the adhesive bond between a film coating and a tablet surface has been studied using a specially designed tensile testing apparatus. The adhesion has been taken as the force required to remove the film from unit area of the tablet surface and has been shown to be dependent on the compression pressure used to prepare the tablet and on changes in the film formulation. Although plasticizers did not show any significant effect on the adhesion of a hydroxypropyl methylcellulose film, a reduction of 45% was found on the addition of 10% w/w titanium dioxide.
使用专门设计的拉伸试验装置研究了薄膜包衣与片剂表面之间的粘合剂结合强度。附着力被视为从片剂表面单位面积去除薄膜所需的力，并且已表明其取决于制备片剂时使用的压缩压力以及薄膜配方的变化。尽管增塑剂对羟丙基甲基纤维素薄膜的附着力没有显示出任何显著影响，但在添加10% w/w二氧化钛后发现附着力降低了45%。
