Sun Jun-Jun, Chu Zhi-Jie, Zhang Yu-Ming, Qi Shi-Fang, Chang Yong-Chao, Xin Shi-Yong, Liu Wei-Feng, Yang Yan-Hui, Zhang Xiao-Hui, Yang Cheng, Yang Tian-Bao
Department of General Surgery, First Affiliated Hospital of Henan University of Science and Technology, Jinghua Road No. 24, Luoyang, 471003, China,
Dig Dis Sci. 2015 Jan;60(1):118-26. doi: 10.1007/s10620-014-3315-z. Epub 2014 Aug 27.
The nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention.
To investigate the influence of VN on the pathophysiological process of ANP in dogs.
The dogs were divided into a sham operation (SO) group, ANP group, ANP + vagal nerve trunk transection (VNTT) group, and ANP + greater splanchnic nerve transection (GSNT) group. The VNTT and GSNT groups underwent VNTT and GSNT respectively immediately after ANP induction. The levels of serum pancreatic amylase (AMY), calcium, high-sensitivity C-reactive protein (HCRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-10 (IL-10) were monitored dynamically and the pathological examinations of the pancreas was performed at postoperative day 7.
All serum parameters among the four groups showed no differences before the experiment (p > 0.05). At different postoperative times, the serum TNF-α, IL-1β, HCRP, and AMY were significantly increased, however, the serum calcium and IL-10 had dropped in the ANP group versus SO group (p < 0.05); an alike variation trend occurred between the VNTT group and ANP group (p < 0.05); an opposite variation trend occurred between the GSNT group and the ANP group (p < 0.05). The pancreas pathological scoring of VNTT group was highest in the four groups (p < 0.05) and GSNT group was lower versus ANP group (p < 0.05).
The GSNT has been shown to alleviate development of ANP, however, VNTT may exacerbate the ANP.
神经系统通过体液和神经通路与免疫系统动态相互作用以调节炎症。然而，内脏神经（VN）对急性坏死性胰腺炎（ANP）的影响鲜有关注。
研究VN对犬急性坏死性胰腺炎病理生理过程的影响。
将犬分为假手术（SO）组、ANP组、ANP + 迷走神经干切断术（VNTT）组和ANP + 内脏大神经切断术（GSNT）组。VNTT组和GSNT组在诱导ANP后立即分别进行VNTT和GSNT。动态监测血清胰淀粉酶（AMY）、钙、高敏C反应蛋白（HCRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-10（IL-10）水平，并在术后第7天进行胰腺病理检查。
四组所有血清参数在实验前无差异（p > 0.05）。在术后不同时间，血清TNF-α、IL-1β、HCRP和AMY显著升高，然而，ANP组与SO组相比血清钙和IL-10下降（p < 0.05）；VNTT组和ANP组之间出现相似的变化趋势（p < 0.05）；GSNT组和ANP组之间出现相反的变化趋势（p < 0.05）。VNTT组的胰腺病理评分在四组中最高（p < 0.05），GSNT组低于ANP组（p < 0.05）。
已表明GSNT可减轻ANP的发展，然而，VNTT可能会加重ANP。
