Taheri Shahram, Keyvandarian Nooshin, Moeinzadeh Firouzeh, Mortazavi Mojgan, Naini Afsoon Emami
Department of Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2014 Jun 25;3:143. doi: 10.4103/2277-9175.135160. eCollection 2014.
End stage renal disease (ESRD) is a condition that inflammation and oxidative stress plays an important role in damaging to tissues, especially, in the vascular system. The effect of omega-3 fatty acids is well-documented in some inflammatory diseases via eicosapentanoic acid and docosahexanoic acid components of fish oil. The aim of this study was to investigate the effects of dietary omega-3 fatty acid supplementation on levels of lipid peroxidation and oxidative sttress in ESRD patients.
This randomized controlled double-blind clinical trial consisted of 90 patients on chronic ambulatory peritoneal dialysis (CAPD). One group was treated orally with 3000 mg omega-3, per day for 8 weeks (n = 45) and the other matched group by placebo (n = 45). Serum levels of lipids, iron, ferritin, Protrombin Time, Partial thromboplastin time, superoxide dismutase (SOD), and reduced glutathione (GH) were measured at the beginning and at 8 weeks.
Our results showed that SOD and reduced GH were not significantly changed in omega-3 group where lipid profile showed no significant changes too. Erythropoietin requirements also had no significant differences.
Incorporation of omega-3 fatty acids to CAPD patients had no beneficial effects on oxidative stress but should evaluate more.
终末期肾病（ESRD）是一种炎症和氧化应激在组织损伤尤其是血管系统损伤中起重要作用的疾病。ω-3脂肪酸的作用在一些炎症性疾病中已通过鱼油中的二十碳五烯酸和二十二碳六烯酸成分得到充分证明。本研究的目的是探讨饮食中补充ω-3脂肪酸对ESRD患者脂质过氧化水平和氧化应激的影响。
这项随机对照双盲临床试验包括90例慢性非卧床腹膜透析（CAPD）患者。一组每天口服3000毫克ω-3，持续8周（n = 45），另一组匹配组服用安慰剂（n = 45）。在开始时和8周时测量血脂、铁、铁蛋白、凝血酶原时间、部分凝血活酶时间、超氧化物歧化酶（SOD）和还原型谷胱甘肽（GH）的血清水平。
我们的结果表明，ω-3组中SOD和还原型GH没有显著变化，血脂水平也没有显著变化。促红细胞生成素的需求量也没有显著差异。
将ω-3脂肪酸纳入CAPD患者对氧化应激没有有益影响，但应进一步评估。
