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丙型肝炎病毒感染中的自噬：抑制脂肪和炎症

Autophagy in HCV infection: keeping fat and inflammation at bay.

作者信息

Vescovo Tiziana, Refolo Giulia, Romagnoli Alessandra, Ciccosanti Fabiola, Corazzari Marco, Alonzi Tonino, Fimia Gian Maria

机构信息

National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.

National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy ; Department of Biology, "Tor Vergata" University of Rome, 00173 Rome, Italy.

出版信息

Biomed Res Int. 2014;2014:265353. doi: 10.1155/2014/265353. Epub 2014 Aug 5.

DOI:10.1155/2014/265353
PMID:25162004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4138948/
Abstract

Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes, including lipid metabolism and innate immunity. Recently, autophagy has emerged as a cellular pathway, playing a role in several aspects of HCV infection. This review summarizes current knowledge on the molecular mechanisms that link the HCV life cycle with autophagy machinery. In particular, we discuss the role of HCV/autophagy interaction in dysregulating inflammation and lipid homeostasis and its potential for translational applications in the treatment of HCV-infected patients.

摘要

丙型肝炎病毒（HCV）感染是慢性肝病的主要病因之一。病毒的持续存在和发病机制主要依赖于HCV破坏特定宿主过程的能力，包括脂质代谢和固有免疫。最近，自噬已成为一种细胞途径，在HCV感染的多个方面发挥作用。本综述总结了目前关于将HCV生命周期与自噬机制联系起来的分子机制的知识。特别是，我们讨论了HCV/自噬相互作用在调节炎症和脂质稳态失调中的作用及其在治疗HCV感染患者中的潜在转化应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa1/4138948/b6c454bb4a4e/BMRI2014-265353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa1/4138948/b6c454bb4a4e/BMRI2014-265353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa1/4138948/b6c454bb4a4e/BMRI2014-265353.001.jpg

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