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认知障碍严重程度作为老年髋部骨折患者死亡率和功能恢复的预后因素

Severity of cognitive impairment as a prognostic factor for mortality and functional recovery of geriatric patients with hip fracture.

作者信息

Tarazona-Santabalbina Francisco José, Belenguer-Varea Ángel, Rovira Daudi Eduardo, Salcedo Mahiques Enmanuel, Cuesta Peredó David, Doménech-Pascual Juan Ramón, Gac Espínola Homero, Avellana Zaragoza Juan Antonio

机构信息

Department of Geriatrics, Hospital Universitario de la Ribera, Alzira, Spain.

出版信息

Geriatr Gerontol Int. 2015 Mar;15(3):289-95. doi: 10.1111/ggi.12271. Epub 2014 Aug 27.

Abstract

AIM

To identify how the severity of dementia influences functional recovery and mortality in elderly patients hospitalized for hip fracture.

METHODS

An observational retrospective study of 1258 patients aged older than 69 years and diagnosed with hip fracture who received care within an orthogeriatrics unit from 2004 to 2008 was carried out. During a 12-month follow-up period, functional recovery and mortality outcomes were measured.

RESULTS

Dementia was present in 383 (28.1%) patients: it was mild in 183 (48%), moderate in 102 (26.5%) and severe in 98 (25.5%). Compared with patients with preserved cognitive status, patients with dementia had the following statistically significant differences (means [standard deviation] or percentage): older age (preserved, 82.29 years [6.5 years]; mild, 83.63 years [6.1 years]; moderate, 83.47 years [5.9 years]; severe, 84.46 years [6.1 years]; P < 0.001); lower Barthel Index (89.7 [21.6], 72.7 [24.6], 58.9 [28.6], 38.0 [28.1]; P < 0.001); delirium (11.7%, 25.6%, 37.6%, 44.7%; P < 0.001); less ambulation at 6 months postdischarge (83.9%, 72.8%, 56.9%, 41.7%; P < 0.001); and higher mortality at discharge (4%, 5.7%, 8.2%, 10.6%; P < 0.001) and 12 months after discharge (21.2%, 32.3%, 46.3%, 53.5%; P < 0.001). Patients with severe dementia had lower probability of functional recovery at discharge (OR 0.272, 95% CI 0.140-0.526, P < 0.001) and 6 months after discharge (OR 0.439, 95% CI 0.197-0.979, P = 0.04), as well as a greater probability of dying (HR 1.640, 95% CI 1.020-2.635, P = 0.04).

CONCLUSIONS

We observed higher 12-month mortality and less functional recovery with increasing severity of dementia.

摘要

目的

确定痴呆严重程度如何影响因髋部骨折住院的老年患者的功能恢复及死亡率。

方法

对2004年至2008年在老年骨科病房接受治疗的1258例69岁以上且被诊断为髋部骨折的患者进行观察性回顾研究。在12个月的随访期内,对功能恢复和死亡率结果进行测量。

结果

383例(28.1%)患者存在痴呆:轻度痴呆183例(48%),中度痴呆102例(26.5%),重度痴呆98例(25.5%)。与认知状态正常的患者相比,痴呆患者在以下方面存在统计学显著差异(均值[标准差]或百分比):年龄更大(认知正常者,82.29岁[6.5岁];轻度痴呆者,83.63岁[6.1岁];中度痴呆者,83.47岁[5.9岁];重度痴呆者,84.46岁[6.1岁];P<0.001);Barthel指数更低(89.7[21.6]、72.7[24.6]、58.9[28.6]、38.0[28.1];P<0.001);谵妄(11.7%、25.6%、37.6%、44.7%;P<0.001);出院后6个月行走能力更差(83.9%、72.8%、56.9%、41.7%;P<0.001);出院时死亡率更高(4%、5.7%、8.2%、10.6%;P<0.001)以及出院后12个月死亡率更高(21.2%、32.3%、46.3%、53.5%;P<0.001)。重度痴呆患者出院时(比值比0.272,95%置信区间0.140 - 0.526,P<0.001)及出院后6个月(比值比0.439,95%置信区间0.197 - 0.979,P = 0.04)功能恢复的可能性更低,死亡可能性更大(风险比1.640,95%置信区间1.020 - 2.635,P = 0.04)。

结论

我们观察到随着痴呆严重程度增加,12个月死亡率更高且功能恢复更少。

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