Pachow Doreen, Wick Wolfgang, Gutmann David H, Mawrin Christian
Department of Neuropathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany (D.P., C.M.); Department of Neurology, Washington University School of Medicine, St Louis, Missouri (D.H.G.); Department of Neuro-Oncology, Neurology Clinic & National Center for Tumor Diseases, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany (W.W.).
Neuro Oncol. 2015 Feb;17(2):189-99. doi: 10.1093/neuonc/nou164. Epub 2014 Aug 27.
Inhibition of the mammalian target of rapamycin (mTOR) signaling pathway has become an attractive target for human cancer therapy. Hyperactivation of mTOR has been reported in both sporadic and syndromic (hereditary) brain tumors. In contrast to the large number of successful clinical trials employing mTOR inhibitors in different types of epithelial neoplasms, their use to treat intracranial neoplasms is more limited. In this review, we summarize the role of mTOR activation in brain tumor pathogenesis and growth relevant to new human brain tumor trials currently under way using mTOR inhibitors.
抑制哺乳动物雷帕霉素靶蛋白(mTOR)信号通路已成为人类癌症治疗中一个有吸引力的靶点。在散发性和综合征性(遗传性)脑肿瘤中均有mTOR过度激活的报道。与在不同类型上皮性肿瘤中使用mTOR抑制剂进行的大量成功临床试验相比,它们在治疗颅内肿瘤方面的应用更为有限。在这篇综述中,我们总结了mTOR激活在脑肿瘤发病机制和生长中的作用,这与目前正在进行的使用mTOR抑制剂的新的人类脑肿瘤试验相关。