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The mTOR signaling pathway as a treatment target for intracranial neoplasms.
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma.
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Role of mTOR in glioblastoma.
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The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.
Clin Cancer Res. 2013 Oct 15;19(20):5722-32. doi: 10.1158/1078-0432.CCR-13-0527. Epub 2013 Sep 12.
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A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
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RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.
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Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.
Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.

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Meningioma: Novel Diagnostic and Therapeutic Approaches.
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Extra-temporal pediatric low-grade gliomas and epilepsy.
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Intramedullary pediatric low-grade glioma of the spine.
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Novel Advances in Treatment of Meningiomas: Prognostic and Therapeutic Implications.
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Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma.
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Medical Treatment of Pediatric Low-Grade Glioma.
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本文引用的文献

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Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer.
Biochem Pharmacol. 2014 Aug 1;90(3):197-207. doi: 10.1016/j.bcp.2014.05.011. Epub 2014 May 24.
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mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma.
Neuro Oncol. 2014 Apr;16(4):493-504. doi: 10.1093/neuonc/not242. Epub 2014 Jan 10.
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mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):409-14. doi: 10.1073/pnas.1314469111. Epub 2013 Dec 23.
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Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Science. 2014 Jan 10;343(6167):189-193. doi: 10.1126/science.1239947. Epub 2013 Dec 12.
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Significance of Akt activation and AKT gene increases in soft tissue tumors.
Hum Pathol. 2014 Jan;45(1):127-36. doi: 10.1016/j.humpath.2013.06.024.

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