Sunshine Joel, Green Jordan J, Mahon Kerry P, Yang Fan, Eltoukhy Ahmed A, Nguyen David N, Langer Robert, Anderson Daniel G
Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore, MD 21205 (USA).
David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
Adv Mater. 2009 Dec 28;21(48):4947-4951. doi: 10.1002/adma.200901718. Epub 2009 Aug 15.
End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.
末端修饰的聚合物有望用于将基因非病毒递送至癌细胞、免疫细胞和人类干细胞,并指出聚合物末端基团是细胞类型特异性的调节剂。已经合成了一个聚合物文库,尽管一些聚合物总体上是强转染剂,但对于每种细胞类型,特定的聚合物最为有效。