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Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.

作者信息

Sunshine Joel, Green Jordan J, Mahon Kerry P, Yang Fan, Eltoukhy Ahmed A, Nguyen David N, Langer Robert, Anderson Daniel G

机构信息

Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore, MD 21205 (USA).

David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).

出版信息

Adv Mater. 2009 Dec 28;21(48):4947-4951. doi: 10.1002/adma.200901718. Epub 2009 Aug 15.

DOI:10.1002/adma.200901718
PMID:25165411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4143259/
Abstract

End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.

摘要

相似文献

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本文引用的文献

[1]
Rapid Optimization of Gene Delivery by Parallel End-modification of Poly(β-amino ester)s.

Mol Ther. 2007-7

[2]
Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Cancer Biol Ther. 2008-10

[3]
Nanoparticles for gene transfer to human embryonic stem cell colonies.

Nano Lett. 2008-10

[4]
A combinatorial polymer library approach yields insight into nonviral gene delivery.

Acc Chem Res. 2008-6

[5]
Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.

Nano Lett. 2007-4

[6]
Biodegradable polymeric vectors for gene delivery to human endothelial cells.

Bioconjug Chem. 2006

[7]
Polymers for gene delivery across length scales.

Nat Mater. 2006-6

[8]
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery.

Pharmacol Rev. 2006-3

[9]
Design and development of polymers for gene delivery.

Nat Rev Drug Discov. 2005-7

[10]
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy.

Mol Ther. 2005-6

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