Deeper, longer phenotyping to accelerate the discovery of the genetic architectures of diseases.
作者信息
Kohane Isaac S
机构信息
Center for Biomedical Informatics, Harvard Medical School, Boston, MA 01115, USA
出版信息
Genome Biol. 2014;15(5):115. doi: 10.1186/gb4175.
Abstract
摘要
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1
Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications.
J Allergy Clin Immunol. 2014 May;133(5):1289-300, 1300.e1-12. doi: 10.1016/j.jaci.2014.02.006.
2
A genotype-first approach to defining the subtypes of a complex disease.
Cell. 2014 Feb 27;156(5):872-7. doi: 10.1016/j.cell.2014.02.002.
3
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.
Nat Genet. 2014 Mar;46(3):294-8. doi: 10.1038/ng.2882. Epub 2014 Jan 26.
4
Comorbidity clusters in autism spectrum disorders: an electronic health record time-series analysis.
Pediatrics. 2014 Jan;133(1):e54-63. doi: 10.1542/peds.2013-0819. Epub 2013 Dec 9.
5
Pathway-based outlier method reveals heterogeneous genomic structure of autism in blood transcriptome.
BMC Med Genomics. 2013 Sep 24;6:34. doi: 10.1186/1755-8794-6-34.
6
Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach.
Inflamm Bowel Dis. 2013 Jun;19(7):1411-20. doi: 10.1097/MIB.0b013e31828133fd.
7
The predictive capacity of personal genome sequencing.
Sci Transl Med. 2012 May 9;4(133):133ra58. doi: 10.1126/scitranslmed.3003380. Epub 2012 Apr 2.
8
Genetic contributions to stability and change in intelligence from childhood to old age.
Nature. 2012 Jan 18;482(7384):212-5. doi: 10.1038/nature10781.
9
Genetic and epigenetic networks in intellectual disabilities.
Annu Rev Genet. 2011;45:81-104. doi: 10.1146/annurev-genet-110410-132512. Epub 2011 Sep 9.
10
Using electronic health records to drive discovery in disease genomics.
Nat Rev Genet. 2011 Jun;12(6):417-28. doi: 10.1038/nrg2999. Epub 2011 May 18.
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