Poldrack Russell A, Laumann Timothy O, Koyejo Oluwasanmi, Gregory Brenda, Hover Ashleigh, Chen Mei-Yen, Gorgolewski Krzysztof J, Luci Jeffrey, Joo Sung Jun, Boyd Ryan L, Hunicke-Smith Scott, Simpson Zack Booth, Caven Thomas, Sochat Vanessa, Shine James M, Gordon Evan, Snyder Abraham Z, Adeyemo Babatunde, Petersen Steven E, Glahn David C, Reese Mckay D, Curran Joanne E, Göring Harald H H, Carless Melanie A, Blangero John, Dougherty Robert, Leemans Alexander, Handwerker Daniel A, Frick Laurie, Marcotte Edward M, Mumford Jeanette A
Department of Psychology, University of Texas, Austin, Texas 78712, USA.
Department of Neuroscience, University of Texas, Austin, Texas 78712, USA.
Nat Commun. 2015 Dec 9;6:8885. doi: 10.1038/ncomms9885.
Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to study the joint dynamics of human brain and metabolic function over time, an approach that is critical for the development of precision medicine strategies for brain disorders.
精神疾病的特点是在数周和数月的时间里心理功能会出现较大波动，但健康个体在这个时间尺度上脑功能的动态特征尚不清楚。在此，作为解决这个问题的概念验证，我们介绍了“我的连接组”项目。在18个月的时间里，对一名个体进行了全表型组的密集评估，包括使用磁共振成像进行脑功能和结构连接性分析、心理功能和身体健康评估、基因表达和代谢组学分析。我们提供了可重复的分析流程，以及数据的开放获取和结果在线浏览器。我们展示了在数天到数月的时间尺度上脑连接性的动态变化，以及脑连接性、基因表达和代谢物之间的关系。这个资源可以作为一个试验台，用于研究人类大脑和代谢功能随时间的联合动态，这种方法对于开发针对脑部疾病的精准医学策略至关重要。
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