The effects of hepatitis B vaccination on infants born to carriers without HBe antigenemia.

A retrospective study on fifty-three patients born to hepatitis B surface antigen (HBs antigen) positive mothers was carried out. Among 17 patients born to hepatitis B e antigen (HBe antigen) negative mothers, six patients received hepatitis B(HB) vaccination and eleven did not. None of the six patients who had received HB vaccination showed seroconversion, while six of the 11 patients (54.5%) without HB vaccination did show seroconversion. There was no definite correlation between the frequency of seroconversion and the administration of HB immune globulin (HBIG). HB vaccination alone may be sufficient to protect infants born to HBe antigen negative mothers from HB viral infection.