Xie Chen, Wu Lingmin, Mei Haibo, Soloshonok Vadim A, Han Jianlin, Pan Yi
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Org Biomol Chem. 2014 Oct 21;12(39):7836-43. doi: 10.1039/c4ob01575d. Epub 2014 Aug 28.
CF3-containing chiral imines readily react with α,α-difluoroenolates affording a novel type of β-keto-amino compounds featuring the R-CO-CF2-CH(NH2)-CF3 moiety. The reactions feature exceptional generality allowing preparation of various aromatic, hetero-aromatic and aliphatic derivatives in high yields and diastereoselectivity. The products are configurationally stable and can be transformed to more functionalized complex compounds.
含CF3的手性亚胺很容易与α,α-二氟烯醇化物反应，生成一种新型的β-酮氨基化合物，其具有R-CO-CF2-CH(NH2)-CF3部分。这些反应具有非凡的通用性，能够以高收率和非对映选择性制备各种芳香族、杂芳香族和脂肪族衍生物。产物构型稳定，可转化为功能更丰富的复杂化合物。
