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Copper-catalyzed three-component synthesis of 3-aminopyrazoles and 4-iminopyrimidines via β-alkynyl-N-sulfonyl ketenimine intermediates.

作者信息

Xing Yanpeng, Cheng Binyu, Wang Jing, Lu Ping, Wang Yanguang

机构信息

Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.

出版信息

Org Lett. 2014 Sep 19;16(18):4814-7. doi: 10.1021/ol502302w. Epub 2014 Aug 28.

DOI:10.1021/ol502302w
PMID:25167465
Abstract

3-Aminopyrazoles and 4-iminopyrimidines were efficiently prepared via copper-catalyzed three-component reactions of butadiynes, sulfonylazides, and hydrazides or imidamides. The reactions were regioselectively approached via the formation of a β-alkynyl-N-sulfonyl ketenimine intermediate which represented a new and effective 1,3-dielectrophilic equivalent in organic synthesis.

摘要

相似文献

1
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2
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