铜催化炔基亚胺与磺酰肼的区域和立体选择性磺酰化反应：合成（）-β-磺酰基烯酮
Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to ()-β-Sulfonyl Enones.
作者信息
Chen Rongxiang, Li Shaozhu, Zhang Jinju, Cao Jing, Wang Kai-Kai, Meng Tuanjie, Liu Lantao
机构信息
School of Pharmacy, Xinxiang University, Xinxiang 453003, PR China.
College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, PR China.
出版信息
J Org Chem. 2022 Oct 7;87(19):13322-13330. doi: 10.1021/acs.joc.2c01192. Epub 2022 Sep 21.
PMID:36129682
Abstract
A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides has been developed, which exhibited excellent regio- and stereoselectivity and furnished a series of ()-β-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy goes through a radical process.
摘要
已开发出一种铜催化的炔基亚胺与磺酰肼的磺酰化反应，该反应表现出优异的区域和立体选择性，并以中等至良好的产率提供了一系列（）-β-磺酰基烯酮。机理研究表明，该策略通过自由基过程进行。
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