Su Hang, Tao Jingyan, Zhang Jie, Xie Ying, Sun Yeming, Li Liren, Xu Ke, Han Bin, Lu Yuling, Sun Haiwei, Wei Youdan, Wang Yue, Zhang Yu, Zou Shengzhen, Wu Wenxiu, Zhang Jiajia, Zhang Xiangyang, He Jincai
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Department of Psychiatry, New Jersey Medical School, Rutgers University, NJ 07103, USA.
Neurosci Lett. 2014 Oct 17;582:16-20. doi: 10.1016/j.neulet.2014.08.030. Epub 2014 Aug 27.
Recent studies showed an association between a functional polymorphism of BDNF gene (Val66Met) and the susceptibility to methamphetamine addiction. We hypothesized that this polymorphism was associated with methamphetamine abuse and impulsivity in methamphetamine-abuse patients. The polymorphism was genotyped in 200 methamphetamine-abuse patients and 219 healthy controls. The association of the Val66Met polymorphism of the BDNF gene and impulsivity in 138 methamphetamine abusers were assessed using Barratt Impulsivity Scale-11(BIS-11) Chinese version. The relationship between the polymorphism and age of onset of methamphetamine abuse was also examined. Our results showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Within the methamphetamine-abuse group, subjects carried the Met allele had significantly higher attentional impulsivity scores of BIS compared to those with the Val/Val genotype. The Met allele was also associated with earlier age onset of methamphetamine use. Our findings suggest that the BDNF Val66Met gene polymorphism may influence attentional impulsivity in methamphetamine abusers. Moreover, the BDNF Val66Met gene polymorphism may contribute to onset age of methamphetamine use.
近期研究表明，脑源性神经营养因子（BDNF）基因的功能性多态性（Val66Met）与甲基苯丙胺成瘾易感性之间存在关联。我们推测，这种多态性与甲基苯丙胺滥用患者的甲基苯丙胺滥用及冲动性有关。对200名甲基苯丙胺滥用患者和219名健康对照者进行了该多态性的基因分型。使用Barratt冲动性量表-11（BIS-11）中文版评估了138名甲基苯丙胺滥用者中BDNF基因Val66Met多态性与冲动性之间的关联。还研究了该多态性与甲基苯丙胺滥用发病年龄之间的关系。我们的结果显示，甲基苯丙胺滥用者与对照组之间在基因型和等位基因分布上无显著差异。在甲基苯丙胺滥用组中，携带Met等位基因的受试者与Val/Val基因型受试者相比，BIS注意力冲动性得分显著更高。Met等位基因还与甲基苯丙胺使用的更早发病年龄相关。我们的研究结果表明，BDNF Val66Met基因多态性可能影响甲基苯丙胺滥用者的注意力冲动性。此外，BDNF Val66Met基因多态性可能与甲基苯丙胺使用的发病年龄有关。
