Qiao Yong, Chen Jinglong, Li Xin, Wei Honglian, Xiao Fan, Chang Lusi, Zhang Renwen, Hao Xiaohua, Wei Hongshan
Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China; Health Science Center, Peking University, Beijing 100083, China.
Clin Biochem. 2014 Nov;47(16-17):216-22. doi: 10.1016/j.clinbiochem.2014.08.010. Epub 2014 Aug 25.
To clarify the role of Golgi membrane glycoprotein 73 (gp73) in evaluating the progression of chronic hepatitis B virus (HBV) infection.
Participants included 958 controls, 421 chronic hepatitis B, 944 hepatic cirrhosis, and 127 hepatocellular carcinoma (HCC) patients. All the patients, with the exception of the controls, were diagnosed HBsAg positive. Serum biomarkers, including gp73, alpha-fetoprotein (AFP), alpha-l-fucosidase, and Lens culinaris agglutinin-reactive fraction of AFP, were determined.
The patients with Hepatic cirrhosis gp73 levels over 150 ng/mL had an odds ratio of 3.21 (95% CI: 2.07-5.00). In hepatic cirrhosis patients, serum gp73 correlated with the Child-Pugh score. gp73 is a marker for diagnosing cirrhosis in the hepatitis populations. When the cut-off was set at 75.5 ng/mL, the sensitivity, specificity, and AUC were 75.6% (95% CI: 71.30%-79.62%), 60.3% (95% CI: 56.95%-63.63%) and 0.72 (95% CI: 0.69-0.75), respectively.
The variation trend of gp73 in chronic liver disease may indicate that monitoring of serum gp73 is helpful to diagnose cirrhosis in population with chronic HBV infection.
阐明高尔基体膜糖蛋白73（gp73）在评估慢性乙型肝炎病毒（HBV）感染进展中的作用。
研究对象包括958名对照者、421例慢性乙型肝炎患者、944例肝硬化患者和127例肝细胞癌（HCC）患者。除对照者外，所有患者均诊断为HBsAg阳性。检测血清生物标志物，包括gp73、甲胎蛋白（AFP）、α-L-岩藻糖苷酶和AFP的扁豆凝集素反应性部分。
肝硬化患者中gp73水平超过150 ng/mL的优势比为3.21（95%可信区间：2.07 - 5.00）。在肝硬化患者中，血清gp73与Child-Pugh评分相关。gp73是肝炎人群中诊断肝硬化的标志物。当临界值设定为75.5 ng/mL时，敏感性、特异性和曲线下面积分别为75.6%（95%可信区间：71.30% - 79.62%）、60.3%（95%可信区间：56.95% - 63.63%）和0.72（95%可信区间：0.69 - 0.75）。
慢性肝病中gp73的变化趋势可能表明，监测血清gp73有助于诊断慢性HBV感染人群中的肝硬化。
