Corada Monica, Morini Marco Francesco, Dejana Elisabetta
From the IFOM, FIRC Institute of Molecular Oncology, Milan, Italy (M.C., M.F.M., E.D.); and Department of Biosciences, University of Milan, Milan, Italy (E.D.).
Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2372-7. doi: 10.1161/ATVBAHA.114.303218. Epub 2014 Aug 28.
The establishment of arterial and venous identity of endothelial cells is critical for the proper anatomic configuration and function of the vascular tree. Arterial and venous specification of endothelial cells is determined by genetic factors, although surrounding cells and hemodynamic forces may also contribute to vascular remodeling. This review provides an overview of the signaling pathways and related transcription factors implicated in differentiation of endothelial cells. We will discuss, in particular, the role of upstream and downstream effectors of Wnt, Sox, and Notch pathways. The understanding of the molecular mechanisms that orchestrate endothelial differentiation may have therapeutic relevance for diseases such as atherosclerosis, arteriovenous malformations, aneurysms, and others.
内皮细胞动脉和静脉特性的建立对于血管树的正常解剖结构和功能至关重要。内皮细胞的动脉和静脉特化由遗传因素决定，尽管周围细胞和血流动力学力也可能有助于血管重塑。本综述概述了与内皮细胞分化相关的信号通路和相关转录因子。我们将特别讨论Wnt、Sox和Notch通路的上游和下游效应器的作用。对协调内皮细胞分化的分子机制的理解可能对动脉粥样硬化、动静脉畸形、动脉瘤等疾病具有治疗意义。
