Ali Ahsan, Yun Sanguk
Department of Biotechnology, Inje University, Gimhae 50834, Republic of Korea.
Biomedicines. 2025 Mar 31;13(4):837. doi: 10.3390/biomedicines13040837.
Notch signaling is evolutionarily conserved from to mammals and it functions as an essential modulator of vascular growth and development by directing endothelial cell specification, proliferation, migration, arteriovenous differentiation, inflammation, and apoptosis. The interplay between Notch and other signaling pathways plays a homeostatic role by modulating multiple vascular functions, including permeability regulation, angiogenesis, and vascular remodeling. This review explores current knowledge on Notch signaling in vascular development, homeostasis, and disease. It also discusses recent developments in understanding how endothelial Notch signaling affects vascular inflammation via cytokines or aberrant shear stress in endothelial cells while addressing the reciprocal relationship between Notch signaling and inflammation.
Notch信号通路在进化上从[原文此处缺失相关物种信息]到哺乳动物都是保守的，它通过指导内皮细胞的特化、增殖、迁移、动静脉分化、炎症和凋亡，作为血管生长和发育的重要调节因子发挥作用。Notch与其他信号通路之间的相互作用通过调节多种血管功能，包括通透性调节、血管生成和血管重塑，发挥稳态作用。本综述探讨了目前关于Notch信号通路在血管发育、稳态和疾病方面的知识。它还讨论了在理解内皮Notch信号通路如何通过细胞因子或内皮细胞中异常切应力影响血管炎症方面的最新进展，同时阐述了Notch信号通路与炎症之间的相互关系。
