Tajiri Naoki, Duncan Kelsey, Borlongan Mia C, Pabon Mibel, Acosta Sandra, de la Pena Ike, Hernadez-Ontiveros Diana, Lozano Diego, Aguirre Daniela, Reyes Stephanny, Sanberg Paul R, Eve David J, Borlongan Cesar V, Kaneko Yuji
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. psanberg@.usf.edu.
Int J Mol Sci. 2014 Aug 28;15(9):15225-43. doi: 10.3390/ijms150915225.
Cell therapy now constitutes an important area of regenerative medicine. The aging of the population has mandated the discovery and development of new and innovative therapeutic modalities to combat devastating disorders such as stroke. Menstrual blood and Sertoli cells represent two sources of viable transplantable cells that are gender-specific, both of which appear to have potential as donor cells for transplantation in stroke. During the subacute phase of stroke, the use of autologous cells offers effective and practical clinical application and is suggestive of the many benefits of using the aforementioned gender-specific cells. For example, in addition to being exceptionally immunosuppressive, testis-derived Sertoli cells secrete many growth and trophic factors and have been shown to aid in the functional recovery of animals transplanted with fetal dopaminergic cells. Correspondingly, menstrual blood cells are easily obtainable and exhibit angiogenic characteristics, proliferative capability, and pluripotency. Of further interest is the ability of menstrual blood cells, following transplantation in stroke models, to migrate to the infarct site, secrete neurotrophic factors, regulate the inflammatory response, and be steered towards neural differentiation. From cell isolation to transplantation, we emphasize in this review paper the practicality and relevance of the experimental and clinical use of gender-specific stem cells, such as Sertoli cells and menstrual blood cells, in the treatment of stroke.
细胞疗法如今已成为再生医学的一个重要领域。人口老龄化促使人们去发现和开发新的创新治疗方法，以对抗诸如中风等严重疾病。月经血和支持细胞是两种可行的可移植细胞来源，它们具有性别特异性，这两种细胞似乎都有潜力作为中风移植的供体细胞。在中风的亚急性期，使用自体细胞可提供有效且实用的临床应用，这表明使用上述性别特异性细胞有诸多益处。例如，睾丸来源的支持细胞除了具有极强的免疫抑制作用外，还能分泌多种生长和营养因子，并且已证明有助于移植胎儿多巴胺能细胞的动物的功能恢复。相应地，月经血细胞易于获取，具有血管生成特性、增殖能力和多能性。更值得关注的是，月经血细胞在中风模型中移植后，能够迁移到梗死部位，分泌神经营养因子，调节炎症反应，并被引导向神经分化。从细胞分离到移植，在这篇综述论文中，我们强调了性别特异性干细胞（如支持细胞和月经血细胞）在中风治疗中的实验和临床应用的实用性及相关性。
