Tallis G A
Division of Clinical Chemistry, Institute of Medical and Veterinary Science, SA.
Aust N Z J Med. 1989 Dec;19(6):730-2. doi: 10.1111/j.1445-5994.1989.tb00349.x.
Three cases of acute lead arsenate poisoning which occurred in South Australia during a 12 month interval are described. The case reports demonstrate a number of features of the characteristic clinical syndrome which may follow ingestion of lead arsenate. The recommended management is immediate gastric lavage and subsequent chelation therapy with calcium EDTA and dimercaprol. Early gastric lavage may prevent significant lead absorption. However, arsenic acid (produced in the stomach when lead arsenate reacts with hydrochloric acid) is relatively water soluble and prompt gastric lavage is unlikely to prevent extensive arsenic absorption. It remains controversial as to whether chelation with dimercaprol prevents arsenical neuropathy.
本文描述了在南澳大利亚州12个月内发生的3例急性砷酸铅中毒病例。病例报告展示了摄入砷酸铅后可能出现的典型临床综合征的一些特征。推荐的处理方法是立即洗胃，随后用依地酸钙钠和二巯丙醇进行螯合治疗。早期洗胃可能会防止大量铅吸收。然而，砷酸（砷酸铅与盐酸在胃中反应生成）相对易溶于水，迅速洗胃不太可能防止大量砷吸收。二巯丙醇螯合是否能预防砷性神经病仍存在争议。
