Gijare P S, Rao K V, Kandarkar S V, Borges A E, Bhide S V
Indian J Exp Biol. 1989 Aug;27(8):685-91.
The utility of hamster cheek pouch model for studies on oral carcinogenesis has been explored using 9,10-dimethyl-1-2-benzanthracene as a carcinogen. Based on the morphological, histopathological and electron microscopic observations the hamster cheek pouch carcinogenesis can be separated into different stages starting from the normal to the fully grown carcinomas. This system is reliable, precise, consistent and can be used for the evaluation of different agents for initiating or promoting effects and as well as for the studies on mechanism of oral carcinogenesis.
利用9,10-二甲基-1,2-苯并蒽作为致癌物，探讨了仓鼠颊囊模型在口腔癌发生研究中的效用。基于形态学、组织病理学和电子显微镜观察，仓鼠颊囊癌发生可分为从正常到完全成熟癌的不同阶段。该系统可靠、精确、一致，可用于评估不同试剂的启动或促进作用，以及用于口腔癌发生机制的研究。
