Guerrero A, García-Ruiz P, Bañares A, Rubio M, Escribá A, García-Urra D, Varela de Seijas E
Neurologia. 1989 Jul-Aug;4(6):216-8.
Lupus anticoagulant (LA) is an immunoglobulin that has been found in association with many diseases and shows an in vitro anticoagulant activity but is clinically associated with thrombosis. We report a patient with a diagnosis of autoimmune disease who developed recurrent transient ischemic attacks; after through investigation of other possible conditions and pathogenetical mechanisms, LA was the only causative factor that was found. We feel that LA should be systematically investigated in cerebrovascular disease, particularly in young patients without other known risk factors, to determine its true incidence and the correct therapeutic approach.
狼疮抗凝物(LA)是一种免疫球蛋白,已发现其与多种疾病相关,具有体外抗凝活性,但在临床上与血栓形成有关。我们报告了一名诊断为自身免疫性疾病的患者,该患者反复发生短暂性脑缺血发作;在对其他可能的情况和发病机制进行全面调查后,发现LA是唯一的致病因素。我们认为,对于脑血管疾病,尤其是没有其他已知危险因素的年轻患者,应该系统地检测LA,以确定其真实发病率和正确的治疗方法。