动态多光子显微镜：聚焦于急性肾损伤的光
Dynamic multiphoton microscopy: focusing light on acute kidney injury.
作者信息
Hall Andrew M, Molitoris Bruce A
机构信息
Institute of Anatomy, University of Zurich, Zurich, Switzerland; and
Indiana University School of Medicine, Indiana Center for Biological Microscopy, Indianapolis, Indiana.
出版信息
Physiology (Bethesda). 2014 Sep;29(5):334-42. doi: 10.1152/physiol.00010.2014.
Abstract
Acute kidney injury (AKI) is a major global health problem; much research has been conducted on AKI, and numerous agents have shown benefit in animal studies, but none have translated into treatments. There is, therefore, a pressing unmet need to increase knowledge of the pathophysiology of AKI. Multiphoton microscopy (MPM) provides a tool to non-invasively visualize dynamic events in real time and at high resolution in rodent kidneys, and in this article we review its application to study novel mechanisms and treatments in different forms of AKI.
摘要
急性肾损伤（AKI）是一个重大的全球健康问题；针对AKI已经开展了大量研究，并且许多药物在动物研究中显示出有益效果，但尚无一种转化为治疗方法。因此，迫切需要增加对AKI病理生理学的了解。多光子显微镜（MPM）提供了一种工具，可在啮齿动物肾脏中实时、高分辨率地非侵入性可视化动态事件，在本文中，我们综述了其在研究不同形式AKI的新机制和治疗方法中的应用。
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本文引用的文献
1
The proximal tubule and albuminuria: really!近端肾小管与白蛋白尿：真的！
J Am Soc Nephrol. 2014 Mar;25(3):443-53. doi: 10.1681/ASN.2013090950. Epub 2014 Jan 9.
2
Advances in multiphoton microscopy technology.多光子显微镜技术的进展。
Nat Photonics. 2013 Feb 1;7(2):93-101. doi: 10.1038/nphoton.2012.361.
3
Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.利用带有荧光谱系标签的新型小鼠模型中的连续多光子成像技术在体内追踪肾小球上皮细胞的命运。
Nat Med. 2013 Dec;19(12):1661-6. doi: 10.1038/nm.3405. Epub 2013 Nov 24.
4
ATP releasing connexin 30 hemichannels mediate flow-induced calcium signaling in the collecting duct.ATP 释放连接蛋白 30 半通道介导集合管中的流动诱导钙信号。
Front Physiol. 2013 Oct 16;4:292. doi: 10.3389/fphys.2013.00292. eCollection 2013.
5
Imaging cell biology in live animals: ready for prime time.在活体动物中进行细胞生物学成像：准备好进入黄金时代。
J Cell Biol. 2013 Jun 24;201(7):969-79. doi: 10.1083/jcb.201212130.
6
World incidence of AKI: a meta-analysis.全球急性肾损伤发病率：一项荟萃分析。
Clin J Am Soc Nephrol. 2013 Sep;8(9):1482-93. doi: 10.2215/CJN.00710113. Epub 2013 Jun 6.
7
Acute kidney injury: an increasing global concern.急性肾损伤：一个日益受到全球关注的问题。
Lancet. 2013 Jul 13;382(9887):170-9. doi: 10.1016/S0140-6736(13)60647-9. Epub 2013 May 31.
8
A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors.一种利用质粒和病毒载体促进和监测大鼠肾脏中外源基因表达的方法。
Am J Physiol Renal Physiol. 2013 May 1;304(9):F1217-29. doi: 10.1152/ajprenal.00070.2013. Epub 2013 Mar 6.
9
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Nat Protoc. 2013 Mar;8(3):583-94. doi: 10.1038/nprot.2013.026. Epub 2013 Feb 21.
10
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PLoS One. 2013;8(1):e52499. doi: 10.1371/journal.pone.0052499. Epub 2013 Jan 21.
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