血清素与感觉神经：在心血管系统中的相遇
Serotonin and sensory nerves: meeting in the cardiovascular system.
作者信息
Watts Stephanie W
机构信息
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA.
出版信息
Vascul Pharmacol. 2014 Oct;63(1):1-3. doi: 10.1016/j.vph.2014.08.003. Epub 2014 Aug 30.
Abstract
Blood pressure regulation by 5-HT has proven to be a complex story to unravel. The work by Cuesta et al., in this issue of Vascular Pharmacology adds another layer of complexity by providing sound in vivo data that 5-HT, through the 5-HT7 receptor, can inhibit the vasodepressor actions of the sensory nervous system and thereby promote blood pressure maintenance. This interaction of 5-HT with the sensory nervous system is inhibitory, whereas 5-HT is understood to be stimulatory in other systems. Moreover, activation of the 5-HT7 receptor has been linked to both reduction and elevation of blood pressure. These interactions are discussed in this mini-review, as are potential steps forward in understanding the interplay of 5-HT, the sensory nervous system and blood pressure.
摘要
5-羟色胺对血压的调节作用已被证明是一个难以厘清的复杂过程。Cuesta等人在本期《血管药理学》上发表的研究成果为这一复杂性增添了新的层面，他们提供了可靠的体内实验数据，表明5-羟色胺通过5-HT7受体可抑制感觉神经系统的血管减压作用，从而有助于维持血压。5-羟色胺与感觉神经系统的这种相互作用是抑制性的，而在其他系统中5-羟色胺被认为具有刺激作用。此外，5-HT7受体的激活与血压降低和升高均有关联。本综述将讨论这些相互作用，以及在理解5-羟色胺、感觉神经系统和血压之间相互作用方面可能取得的进展。
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