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8-OH-DPAT对5-HT7受体的刺激可抵消5-HT(1A)受体刺激对小鼠情境学习的损害作用。

5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT(1A) receptor stimulation on contextual learning in mice.

作者信息

Eriksson Therese M, Golkar Armita, Ekström Joanna C, Svenningsson Per, Ogren Sven Ove

机构信息

Department of Neuroscience, Division of Behavioral Neuroscience, Karolinska Institute, Stockholm, Sweden.

出版信息

Eur J Pharmacol. 2008 Oct 31;596(1-3):107-10. doi: 10.1016/j.ejphar.2008.08.026. Epub 2008 Aug 29.

DOI:10.1016/j.ejphar.2008.08.026
PMID:18789922
Abstract

The principal 5-HT(1A) receptor agonist 8-Hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) impairs several different types of learning. Besides 5-HT(1A) receptors, 8-OH-DPAT stimulates 5-HT(7) receptors, but it is not known whether 5-HT(7) receptors contribute to the impairments. The 5-HT(7) receptor antagonist (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl] pyrrolidine (SB-269970) was combined with 8-OH-DPAT to dissociate 5-HT(1A) from 5-HT(7) receptor-mediated effects, in the passive avoidance task for emotional learning. SB-269970 intensified impairments caused by 8-OH-DPAT. SB-269970 alone had no effect on memory performance, but moderately decreased retention under suboptimal learning conditions. These findings indicate that 5-HT(7) receptor stimulation by 8-OH-DPAT counteracts 5-HT(1A) receptor-mediated impairments in hippocampal-dependent contextual learning.

摘要

主要的5-羟色胺（5-HT）(1A) 受体激动剂8-羟基-2-（二丙基氨基）四氢萘（8-OH-DPAT）会损害几种不同类型的学习。除了5-HT(1A) 受体外，8-OH-DPAT还能刺激5-HT(7) 受体，但尚不清楚5-HT(7) 受体是否导致了这些损害。在用于情绪学习的被动回避任务中，5-HT(7) 受体拮抗剂（2R）-1-[(3-羟基苯基)磺酰基]-2-[2-(4-甲基-1-哌啶基)乙基]吡咯烷（SB-269970）与8-OH-DPAT联合使用，以区分5-HT(1A) 受体和5-HT(7) 受体介导的效应。SB-269970加剧了8-OH-DPAT引起的损害。单独使用SB-269970对记忆表现没有影响，但在次优学习条件下会适度降低记忆保持能力。这些发现表明，8-OH-DPAT对5-HT(7) 受体的刺激抵消了5-HT(1A) 受体介导的海马依赖性情境学习损害。

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