新型ATP 2-硫代衍生物的合成及生物活性
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP.
作者信息
Zimmet J, Järlebark L, Hammarberg T, van Galen P J M, Jacobson K A, Heilbronn E
机构信息
Unit of Neurochemistry and Neurotoxicology, Stockholm University, 106 91 Stockholm, Sweden.
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.
出版信息
Nucleosides Nucleotides. 1993;12(1):1-20. doi: 10.1080/07328319308016190.
Abstract
2-Alkylthio analogues of adenosine 5'-triphosphate were synthesized and evaluated as P purinoceptor agonists. ATP and analogues transiently increased intracellular Ca levels in C6 glioma cells and in skeletal muscle derived myotubes in culture. Most derivatives were resistant to stepwise dephosphorylation by ecto-ATPases.
摘要
合成了腺苷 5'-三磷酸的 2-烷硫基类似物，并将其作为嘌呤受体激动剂进行评估。ATP 及其类似物可使培养的 C6 胶质瘤细胞和骨骼肌衍生的肌管中的细胞内钙水平短暂升高。大多数衍生物对胞外 ATP 酶的逐步去磷酸化具有抗性。
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