Secco G B, Fardelli R, Rovida S, Ratto G B, Capponi G, Fabiano F, Motta G
G Chir. 1989 Oct;10(10):557-61.
A retrospective analysis has been carried out on a group of 103 Dukes C cases from a series of 412 patients with colorectal carcinoma, operated on from January 1970 to November 1983. The 5-year survival rate was 32% in patients who had a curative resection (median survival: 24 months). Larger numbers of lymph nodes were obtained with right or left colectomy. As regards the treatment of rectal cancer, similar numbers of nodes were obtained either with anterior resection or with Miles' operation. Prognosis was significantly correlated to tumor location, number of involved nodes (p less than 0.01) and grading of the primary tumor (p less than 0.01). The use of extended left colectomy with elective abdominopelvic lymphadenectomy was associated with a small raise of survival and a definite increase of perioperative morbidity and mortality compared to conservative surgical resection.
对1970年1月至1983年11月期间接受手术治疗的412例结直肠癌患者中的103例Dukes C期病例进行了回顾性分析。行根治性切除的患者5年生存率为32%（中位生存期：24个月）。右半结肠切除术或左半结肠切除术获取的淋巴结数量更多。关于直肠癌的治疗，前切除术或Miles手术获取的淋巴结数量相近。预后与肿瘤位置、受累淋巴结数量（p<0.01）及原发肿瘤分级（p<0.01）显著相关。与保守性手术切除相比，采用扩大左半结肠切除术并选择性行腹盆腔淋巴结清扫术可使生存率略有提高，但围手术期发病率和死亡率明显增加。
