芝麻粗水提取物和甲醇提取物的高效液相色谱分析及细胞表面受体结合活性
HPLC analysis and cell surface receptor binding activities of the crude aqueous and methanolic extract of Sesamum indicum.
作者信息
Saha Repon Kumer, Dinar Md Abu Monsur, Nabila Kausain Akther, Roy Priyanka
机构信息
Department of Pharmacy, East West University, Dhaka, Bangladesh.
Dhaka Medical College, Dhaka, Bangladesh.
出版信息
Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S516-20. doi: 10.12980/APJTB.4.2014C973.
OBJECTIVE
To identify the possible functional molecules for therapeutic uses by screening the crude aqueous and methanolic extracts derived from sesame seeds (Sesamum indicum) in vitro.
METHODS
High performance liquid chromatography was used to scan the functional molecules present in the extracts.
RESULTS
The crude aqueous extracts showed the possibilities to present caffeine and cetirizine or its derivatives like molecules. On the other hand, the crude methanolic extract may contain Loratadine or its derivatives like molecules. Both type of extracts showed hemagglutination inhibition activities in all types of human blood samples tested. However, they showed stronger binding with AB+ blood group than those of A+ and B+ blood.
CONCLUSIONS
Sesame seeds may be considered as a functional food.
目的
通过体外筛选芝麻（Sesamum indicum）的水提物和甲醇提取物，确定可能用于治疗用途的功能分子。
方法
采用高效液相色谱法扫描提取物中存在的功能分子。
结果
水提物显示可能含有咖啡因和西替利嗪或其类似分子的衍生物。另一方面，甲醇提取物可能含有氯雷他定或其类似分子的衍生物。两种提取物在所有测试的人类血液样本中均表现出血凝抑制活性。然而，它们与AB+血型的结合比A+和B+血型更强。
结论
芝麻可被视为一种功能性食品。
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